Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   RRU92_RS05795 Genome accession   NZ_CP135436
Coordinates   1202104..1202775 (+) Length   223 a.a.
NCBI ID   WP_075229131.1    Uniprot ID   A0A1F0NFC7
Organism   Streptococcus sp. DTU_2020_1001019_1_SI_AUS_MUR_006     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1197104..1207775
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RRU92_RS05775 (RRU92_05775) - 1197553..1198062 (+) 510 Protein_1087 NUDIX hydrolase -
  RRU92_RS05780 (RRU92_05780) - 1198034..1198882 (+) 849 WP_315638902.1 putative PEP-binding protein -
  RRU92_RS05785 (RRU92_05785) - 1198879..1199319 (+) 441 WP_315638903.1 ASCH domain-containing protein -
  RRU92_RS05790 (RRU92_05790) - 1199442..1201988 (+) 2547 WP_315640913.1 M1 family metallopeptidase -
  RRU92_RS05795 (RRU92_05795) ciaR 1202104..1202775 (+) 672 WP_075229131.1 response regulator transcription factor Regulator
  RRU92_RS05800 (RRU92_05800) ciaH 1202768..1204102 (+) 1335 WP_315638905.1 HAMP domain-containing sensor histidine kinase Regulator
  RRU92_RS05805 (RRU92_05805) - 1204210..1204485 (-) 276 WP_070460932.1 DUF3270 family protein -
  RRU92_RS05810 (RRU92_05810) - 1204624..1205553 (+) 930 WP_315638907.1 peptidase U32 family protein -
  RRU92_RS05815 (RRU92_05815) rpiA 1205659..1206342 (+) 684 WP_315638909.1 ribose-5-phosphate isomerase RpiA -
  RRU92_RS05820 (RRU92_05820) - 1206371..1207582 (+) 1212 WP_315638911.1 phosphopentomutase -

Sequence

Protein


Download         Length: 223 a.a.        Molecular weight: 25320.11 Da        Isoelectric Point: 4.3826

>NTDB_id=886545 RRU92_RS05795 WP_075229131.1 1202104..1202775(+) (ciaR) [Streptococcus sp. DTU_2020_1001019_1_SI_AUS_MUR_006]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDLTVNLSTNEVKVNDTVVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGSVFAENLQTLRSVGYILKHV

Nucleotide


Download         Length: 672 bp        

>NTDB_id=886545 RRU92_RS05795 WP_075229131.1 1202104..1202775(+) (ciaR) [Streptococcus sp. DTU_2020_1001019_1_SI_AUS_MUR_006]
ATGATCAAAATTCTATTAGTGGAAGATGACCTAGGCCTGTCAAATTCAGTCTTTGATTTTTTGGATGATTTTGCGGATGT
CATGCAGGTTTTTGATGGAGAAGAAGGTCTTTATGAGGCTGAAAGTGGCGTTTATGATTTGATTCTGCTTGATTTGATGT
TGCCTGAAAAAAATGGTTTCCAAGTCTTGAAAGAATTACGTGAAAAAGGCGTTTCGACACCAGTTCTTATCATGACAGCA
AAGGAAAGTCTCGATGACAAAGGTCATGGATTTGAGCTTGGGGCAGATGATTATCTAACAAAACCATTCTACCTAGAAGA
ACTCAAGATGCGTATTCAGGCGCTGCTCAAACGTTCTGGTAAGTTCAACGAAAATACTCTTTCTTATGGTGATTTGACTG
TCAATCTATCTACCAATGAGGTTAAAGTCAATGATACTGTTGTGGAATTATTGGGTAAAGAATTTGATCTTTTGGTTTAT
TTCCTCCAAAATCAAAATGTTATCTTACCAAAAACACAAATTTTTGACCGTTTGTGGGGATTTGACAGTGACACAACCAT
CTCCGTGGTAGAAGTCTATGTATCAAAAGTTCGTAAGAAATTAAAGGGCTCAGTCTTTGCTGAAAACCTCCAAACCTTGC
GTAGTGTTGGGTATATTTTAAAACATGTTTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(147-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1F0NFC7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

94.17

100

0.942
  ciaR Streptococcus pneumoniae D39

94.17

100

0.942
  ciaR Streptococcus pneumoniae R6

94.17

100

0.942
  ciaR Streptococcus pneumoniae TIGR4

94.17

100

0.942
  ciaR Streptococcus mutans UA159

88.235

99.103

0.874
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.778

100

0.381
  vicR Streptococcus mutans UA159

36.052

100

0.377