NTDB

Overview

Name	vicR	Type	Regulator
Locus tag	QN329_RS09260	Genome accession	NZ_CP135103
Coordinates	1810794..1811504 (-)	Length	236 a.a.
NCBI ID	WP_000722052.1	Uniprot ID	X5K3L1
Organism	Streptococcus agalactiae strain HU36/21
Function	repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1805794..1816504

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QN329_RS09240 (QN329_09245)	rnc	1807407..1808093 (-)	687	WP_000661527.1	ribonuclease III	-
QN329_RS09245 (QN329_09250)	-	1808268..1808636 (-)	369	WP_000719384.1	YbaN family protein	-
QN329_RS09250 (QN329_09255)	vicX	1808639..1809448 (-)	810	WP_001289498.1	MBL fold metallo-hydrolase	Regulator
QN329_RS09255 (QN329_09260)	vicK	1809452..1810801 (-)	1350	WP_001065469.1	cell wall metabolism sensor histidine kinase VicK	Regulator
QN329_RS09260 (QN329_09265)	vicR	1810794..1811504 (-)	711	WP_000722052.1	response regulator YycF	Regulator
QN329_RS09265 (QN329_09270)	-	1811843..1812598 (+)	756	WP_000053148.1	amino acid ABC transporter ATP-binding protein	-
QN329_RS09270 (QN329_09275)	-	1812610..1813410 (+)	801	WP_000946173.1	transporter substrate-binding domain-containing protein	-
QN329_RS09275 (QN329_09280)	-	1813423..1814118 (+)	696	WP_000173639.1	amino acid ABC transporter permease	-
QN329_RS09280 (QN329_09285)	-	1814130..1814780 (+)	651	WP_000100034.1	amino acid ABC transporter permease	-
QN329_RS09285 (QN329_09290)	-	1814829..1815395 (-)	567	WP_000592388.1	PepSY domain-containing protein	-

Sequence

Protein

Download Length: 236 a.a. Molecular weight: 27063.90 Da Isoelectric Point: 4.8246

                                >NTDB_id=885392 QN329_RS09260 WP_000722052.1 1810794..1811504(-) (vicR) [Streptococcus agalactiae strain HU36/21]

MKKILIVDDEKPISDIIKFNLTKEGYETATAFDGREALVQYAEFQPDLIILDLMLPELDGLEVAKEVRKTSHIPIIMLSA

KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIETAVAEESAQNASSDITIGELQILPDAFIAKKRGEEIE

LTHREFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPGRPEYILTRRGVGYYMKSYE

Nucleotide

Download Length: 711 bp

                                >NTDB_id=885392 QN329_RS09260 WP_000722052.1 1810794..1811504(-) (vicR) [Streptococcus agalactiae strain HU36/21]

ATGAAAAAAATACTTATCGTTGATGATGAAAAACCAATTTCAGATATTATCAAATTTAATTTAACCAAAGAAGGATATGA

GACAGCGACAGCTTTCGATGGCCGTGAAGCTTTAGTACAATATGCAGAATTTCAACCAGATTTAATCATTTTGGATTTAA

TGCTCCCTGAACTAGATGGTTTAGAAGTGGCTAAGGAAGTTCGTAAAACCAGCCATATTCCTATTATTATGCTTTCTGCA

AAAGATAGTGAGTTTGACAAAGTCATTGGTTTAGAAATCGGTGCAGATGATTATGTTACTAAACCTTTTTCAAATCGTGA

ACTTTTAGCACGGGTCAAAGCACATTTACGACGTACTGAAAATATTGAAACAGCTGTAGCAGAAGAAAGCGCTCAAAATG

CTTCTTCAGATATTACTATTGGTGAGTTGCAAATTTTACCAGACGCCTTTATTGCTAAGAAACGTGGCGAAGAAATTGAA

TTAACGCACCGAGAATTTGAATTACTTCACCATTTAGCGACACATATCGGACAAGTCATGACACGCGAACATTTATTGGA

AACGGTTTGGGGATATGATTATTTTGGAGATGTCCGTACAGTTGATGTGACGGTGAGACGTTTACGTGAAAAGATTGAAG

ATACTCCTGGTCGTCCAGAATATATTTTGACTCGACGTGGTGTAGGTTATTACATGAAGTCTTATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)

Response regulator receiver domain (Response_reg)

(4-113)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	X5K3L1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
vicR	Streptococcus mutans UA159	88.983	100	0.89
micA	Streptococcus pneumoniae Cp1015	77.778	99.153	0.771
covR	Lactococcus lactis subsp. lactis strain DGCC12653	46.983	98.305	0.462
covR	Streptococcus salivarius strain HSISS4	44.635	98.729	0.441
scnR	Streptococcus mutans UA159	38.559	100	0.386

Detailed information NTG0885392