Detailed information NTG0880237

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: RJW49_RS10340
• Genome accession: NZ_CP134477
• Coordinates: 2051196..2052392 (+)
• Length: 398 a.a.
• NCBI ID: WP_014736606.1
• Uniprot ID: A0A3R8NMN8
• Organism: Streptococcus suis strain NLS40
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2046196..2057392

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RJW49_RS10310 (RJW49_10310)	-	2046855..2049434 (+)	2580	WP_014736604.1	YfhO family protein	-
RJW49_RS10330 (RJW49_10330)	-	2049835..2050518 (-)	684	WP_012775416.1	YoaK family protein	-
RJW49_RS10335 (RJW49_10335)	rlmH	2050543..2051022 (-)	480	WP_002941741.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
RJW49_RS10340 (RJW49_10340)	htrA	2051196..2052392 (+)	1197	WP_014736606.1	S1C family serine protease	Regulator
RJW49_RS10345 (RJW49_10345)	spo0J	2052453..2053217 (+)	765	WP_014736607.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 398 a.a.
• Molecular weight: 41790.78 Da
• Isoelectric Point: 4.5940

>NTDB_id=880237 RJW49_RS10340 WP_014736606.1 2051196..2052392(+) (htrA) [Streptococcus suis strain NLS40]
MERIPYMKKYLKFAILFVIGFFGGLIGALSASFFQPQVQQANSAITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGAIFGNIESSDELAVAGEGSGVIYKKDGQYAYIVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTAVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSKDGQTISTNAIQTDTAINPGNSGGPLIN
TQGQVIGITSSKITSSSANSSGVAVEGLGFAIPANDAVAIINQLEKTGQVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGEAIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE

Nucleotide

• Length: 1197 bp

>NTDB_id=880237 RJW49_RS10340 WP_014736606.1 2051196..2052392(+) (htrA) [Streptococcus suis strain NLS40]
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTTTATTTGTAATTGGATTTTTTGGGGGTCTTATCGG
GGCCTTATCAGCCTCTTTCTTCCAGCCACAGGTGCAACAAGCAAATTCTGCTATCACTAGTGTCAGCAATGTTCAATATA
ATAATGAAACTTCCACCACAAAAGCTGTAGAGAAAGTACAAAATGCTGTTGTGTCTGTTATTAATTACCAAAAATCAGCC
AACAATAGTCTTGGTGCTATCTTTGGAAATATTGAATCATCTGACGAACTAGCTGTTGCTGGAGAGGGGTCTGGGGTTAT
CTATAAAAAAGATGGTCAATATGCCTATATTGTGACAAATACGCATGTTATTAATAACGCAGAAAAGATTGATATCCTTT
TAGCATCTGGAGAAAAAATTAGCGGTGAACTTGTTGGTTCCGATACATATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTGCTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGCGTCTACGCCAATACAGTTACCCAGGGTATTATTTCTAGCTTAAGTCGGACAGTCACTTCACAATCAAAAG
ATGGACAAACAATCTCAACTAACGCTATTCAAACTGATACAGCTATCAACCCTGGAAACTCTGGCGGACCGTTAATCAAT
ACCCAAGGACAAGTGATAGGCATTACCTCTAGCAAAATTACCTCAAGTTCTGCAAATAGCTCAGGCGTGGCTGTAGAAGG
GTTGGGATTTGCTATTCCTGCAAATGATGCCGTAGCTATTATCAATCAGCTTGAAAAAACTGGACAAGTTAGCCGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTAGAAAAAGCTGGATTATCAAATACGGAATTA
ACATCCGGTGTAGTAATTGTCTCTACACAAAGTGGGCTACCTGCAGATGGAAAATTAGAAACTTTTGATGTTATTACTGA
GATTGACGGAGAAGCTATTCAAAATAAGAGTGACCTCCAGAGCGCTCTCTACAAACATCAAATTGGAGATACAATCACTG
TAACTTATTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (293-389)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

3D structure

• AlphaFold DB: A0A3R8NMN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	59.446	99.749	0.593
htrA	Streptococcus gordonii str. Challis substr. CH1	59.494	99.246	0.59
htrA	Streptococcus pneumoniae D39	57.252	98.744	0.565
htrA	Streptococcus pneumoniae TIGR4	57.252	98.744	0.565
htrA	Streptococcus mitis NCTC 12261	57.252	98.744	0.565
htrA	Streptococcus pneumoniae R6	57.252	98.744	0.565
htrA	Streptococcus pneumoniae Rx1	57.252	98.744	0.565