Detailed information NTG0880169

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: RJW55_RS05020
• Genome accession: NZ_CP134473
• Coordinates: 1060357..1061028 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain TMW_SS028
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1055357..1066028

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RJW55_RS04990 (RJW55_04990)	pstC	1055556..1056473 (+)	918	WP_024406095.1	phosphate ABC transporter permease subunit PstC	-
RJW55_RS04995 (RJW55_04995)	pstA	1056463..1057350 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
RJW55_RS05000 (RJW55_05000)	pstB	1057375..1058178 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
RJW55_RS05005 (RJW55_05005)	pstB	1058190..1058948 (+)	759	WP_043024749.1	phosphate ABC transporter ATP-binding protein PstB	-
RJW55_RS05010 (RJW55_05010)	phoU	1058977..1059633 (+)	657	WP_043033622.1	phosphate signaling complex protein PhoU	-
RJW55_RS05015 (RJW55_05015)	-	1059782..1060162 (+)	381	WP_043025691.1	hypothetical protein	-
RJW55_RS05020 (RJW55_05020)	ciaR	1060357..1061028 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
RJW55_RS05025 (RJW55_05025)	ciaH	1061021..1062400 (+)	1380	WP_043025694.1	cell wall metabolism sensor histidine kinase WalK	Regulator
RJW55_RS05030 (RJW55_05030)	-	1062500..1063729 (+)	1230	WP_043025695.1	transglutaminase domain-containing protein	-
RJW55_RS05035 (RJW55_05035)	rpsT	1063994..1064242 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
RJW55_RS05040 (RJW55_05040)	coaA	1064301..1065221 (-)	921	WP_002935283.1	type I pantothenate kinase	-
RJW55_RS05045 (RJW55_05045)	-	1065330..1065920 (+)	591	WP_043025697.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=880169 RJW55_RS05020 WP_014637852.1 1060357..1061028(+) (ciaR) [Streptococcus suis strain TMW_SS028]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=880169 RJW55_RS05020 WP_014637852.1 1060357..1061028(+) (ciaR) [Streptococcus suis strain TMW_SS028]
ATGATTAAGATTTTGTTAGTAGAAGACGATTTAAGCCTATCCAATTCAGTTTTTGACTTCCTAGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAAGAAGGAATCTATGAAGCGGAAACTGGTGTGTACGACTTAATTTTATTAGATTTAATGT
TACCTGAAAAAGACGGCTTTCAAGTCTTGAAAGAGTTACGTGAAAAAGGTGTTACAACTCCTGTCTTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGCGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGATGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTGGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCCAAAACTCAAATTTTTGATAGAATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTATATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368