Detailed information NTG0874676

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: RDV59_RS07160
• Genome accession: NZ_CP133476
• Coordinates: 1448131..1448805 (-)
• Length: 224 a.a.
• NCBI ID: WP_002891134.1
• Uniprot ID: J7TS49
• Organism: Streptococcus salivarius strain LMG 11489
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1443131..1453805

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RDV59_RS07135 (RDV59_07135)	-	1443445..1444722 (-)	1278	WP_014634600.1	pyrimidine-nucleoside phosphorylase	-
RDV59_RS07140 (RDV59_07140)	-	1444719..1445309 (-)	591	WP_014633038.1	class I SAM-dependent methyltransferase	-
RDV59_RS07145 (RDV59_07145)	coaA	1445422..1446342 (+)	921	WP_038676170.1	type I pantothenate kinase	-
RDV59_RS07150 (RDV59_07150)	rpsT	1446412..1446648 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
RDV59_RS07155 (RDV59_07155)	ciaH	1446726..1448141 (-)	1416	WP_004182392.1	cell wall metabolism sensor histidine kinase WalK	Regulator
RDV59_RS07160 (RDV59_07160)	ciaR	1448131..1448805 (-)	675	WP_002891134.1	response regulator transcription factor	Regulator
RDV59_RS07165 (RDV59_07165)	-	1449003..1450673 (-)	1671	WP_004182072.1	formate--tetrahydrofolate ligase	-
RDV59_RS07170 (RDV59_07170)	-	1450868..1451551 (+)	684	WP_022496696.1	phosphopantothenate--cysteine ligase	-
RDV59_RS07175 (RDV59_07175)	coaC	1451544..1452089 (+)	546	WP_022496697.1	phosphopantothenoylcysteine decarboxylase	-
RDV59_RS07180 (RDV59_07180)	-	1452118..1452690 (+)	573	WP_022496698.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.02 Da
• Isoelectric Point: 4.2897

>NTDB_id=874676 RDV59_RS07160 WP_002891134.1 1448131..1448805(-) (ciaR) [Streptococcus salivarius strain LMG 11489]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=874676 RDV59_RS07160 WP_002891134.1 1448131..1448805(-) (ciaR) [Streptococcus salivarius strain LMG 11489]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGACGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAACGTAATTTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTTGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAATCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: J7TS49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362