Detailed information NTG0874560

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: RDV58_RS00890
• Genome accession: NZ_CP133475
• Coordinates: 174687..175895 (+)
• Length: 402 a.a.
• NCBI ID: WP_002262650.1
• Uniprot ID: Q8DRQ6
• Organism: Streptococcus mutans strain LMG 14558
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 169687..180895

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RDV58_RS00880 (RDV58_00880)	-	172997..173659 (-)	663	WP_002262652.1	YoaK family protein	-
RDV58_RS00885 (RDV58_00885)	rlmH	174002..174481 (-)	480	WP_002262651.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
RDV58_RS00890 (RDV58_00890)	htrA	174687..175895 (+)	1209	WP_002262650.1	S1C family serine protease	Regulator
RDV58_RS00895 (RDV58_00895)	spo0J	176362..177132 (+)	771	WP_002269456.1	ParB/RepB/Spo0J family partition protein	Regulator
RDV58_RS00900 (RDV58_00900)	dnaA	177334..178692 (+)	1359	WP_002262648.1	chromosomal replication initiator protein DnaA	-
RDV58_RS00905 (RDV58_00905)	dnaN	178848..179984 (+)	1137	WP_002262647.1	DNA polymerase III subunit beta	-
RDV58_RS00910 (RDV58_00910)	-	180257..180448 (+)	192	WP_002262646.1	DUF951 domain-containing protein	-

Sequence

Protein

• Length: 402 a.a.
• Molecular weight: 43071.55 Da
• Isoelectric Point: 8.8092

>NTDB_id=874560 RDV58_RS00890 WP_002262650.1 174687..175895(+) (htrA) [Streptococcus mutans strain LMG 14558]
MNNTKSHPFLKWFIPFLVIFLTFILGVISTLTFNWITGNKSFSNNGKTTVSNVIYDTKSNTTKAVKNVKNTVVSVINYQK
TDNSYYNYDSGSQEKNKSEDGLGVYGEGSGVIYKKDGDSAYLVTNNHVVKDAEKLEIMMANGKKVVGKLVGSDTYSDLAV
IKISSKYVTTVAEFANSDKIKVGEPAIAIGSPLGSDYANSVTEGIVSSLSRTVTSQNENGETISTNAIQTDAAINPGNSG
GALINIKGQVIGINSSKIASSNNSNSGVAVEGMGFAIPSNDVVSIINQLEENGEVVRPALGISMANLSEASTSGRDTLKI
PSDVTSGIVVLSTQSGMPADGKLKKYDVITEIDGKKVASISDLQSILYKHKKGDKIKLTFYREKDKQTVEIQLTKTSQDL
NH

Nucleotide

• Length: 1209 bp

>NTDB_id=874560 RDV58_RS00890 WP_002262650.1 174687..175895(+) (htrA) [Streptococcus mutans strain LMG 14558]
GTGAATAATACGAAATCTCACCCTTTTTTAAAATGGTTTATACCTTTTTTAGTTATTTTTTTAACTTTTATTTTAGGGGT
CATATCAACACTTACCTTTAATTGGATAACTGGTAACAAATCGTTTTCTAACAATGGAAAAACAACTGTTAGTAATGTCA
TTTATGATACCAAATCTAACACTACCAAGGCTGTTAAAAATGTCAAAAATACAGTTGTATCTGTCATCAATTATCAAAAA
ACAGATAATAGTTATTACAATTATGACAGCGGTTCTCAAGAAAAAAATAAATCAGAGGATGGTCTAGGAGTCTACGGTGA
AGGTTCTGGTGTTATCTATAAAAAAGATGGCGATAGTGCTTATTTAGTTACAAACAATCATGTCGTTAAAGATGCAGAAA
AGTTAGAAATCATGATGGCTAATGGTAAAAAAGTTGTCGGTAAATTAGTAGGTTCTGATACTTATTCTGATCTGGCTGTT
ATTAAAATTTCTTCTAAGTATGTTACGACAGTTGCTGAATTTGCTAATTCGGATAAAATAAAAGTTGGAGAACCAGCAAT
CGCTATTGGTAGCCCTTTAGGCAGTGATTATGCTAATTCTGTAACAGAAGGAATTGTTTCAAGTCTCAGTCGTACAGTAA
CTTCACAAAATGAAAATGGCGAAACAATTTCAACTAATGCTATTCAAACAGACGCAGCTATTAACCCTGGTAATTCTGGT
GGCGCTTTAATTAATATCAAAGGACAAGTTATTGGTATCAATTCAAGTAAAATTGCATCAAGTAATAACTCAAATAGTGG
CGTTGCTGTTGAAGGAATGGGCTTTGCAATTCCTTCAAACGATGTTGTCTCTATTATTAATCAATTAGAAGAAAATGGTG
AAGTTGTTAGACCCGCTCTTGGTATTTCAATGGCTAATCTTAGTGAAGCTTCAACAAGTGGAAGAGATACTTTAAAAATA
CCAAGTGATGTCACAAGCGGTATTGTTGTTCTTTCAACACAAAGTGGTATGCCAGCAGATGGGAAGCTGAAGAAATATGA
TGTCATTACAGAAATTGATGGGAAGAAGGTAGCGTCTATCAGCGATCTTCAAAGTATTCTTTACAAACACAAAAAGGGAG
ATAAAATTAAACTCACTTTCTATCGCGAAAAAGATAAACAAACAGTTGAGATCCAATTAACTAAAACAAGTCAAGATTTG
AATCATTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (298-393)

• Trypsin-like peptidase domain (Trypsin_2) (108-253)

• Peptidase family M50 (Peptidase_M50) (227-398)

3D structure

• AlphaFold DB: Q8DRQ6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	100	100	1
htrA	Streptococcus gordonii str. Challis substr. CH1	56.14	99.254	0.557
htrA	Streptococcus mitis NCTC 12261	54.684	98.259	0.537
htrA	Streptococcus pneumoniae Rx1	54.315	98.01	0.532
htrA	Streptococcus pneumoniae D39	54.315	98.01	0.532
htrA	Streptococcus pneumoniae R6	54.315	98.01	0.532
htrA	Streptococcus pneumoniae TIGR4	54.315	98.01	0.532