Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   RDV54_RS01770 Genome accession   NZ_CP133471
Coordinates   336539..337873 (+) Length   444 a.a.
NCBI ID   WP_000491799.1    Uniprot ID   A0AAX2L9N6
Organism   Streptococcus mitis strain LMG 14557     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 331539..342873
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RDV54_RS01745 (RDV54_01745) - 331699..331935 (+) 237 WP_000141913.1 DUF2829 domain-containing protein -
  RDV54_RS01750 (RDV54_01750) - 331928..332626 (+) 699 WP_000198458.1 3-oxoacyl-ACP reductase -
  RDV54_RS01755 (RDV54_01755) - 332657..333097 (+) 441 WP_000188805.1 ASCH domain-containing protein -
  RDV54_RS01760 (RDV54_01760) - 333220..335766 (+) 2547 WP_001149091.1 M1 family metallopeptidase -
  RDV54_RS01765 (RDV54_01765) ciaR 335875..336549 (+) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  RDV54_RS01770 (RDV54_01770) ciaH 336539..337873 (+) 1335 WP_000491799.1 two-component system sensor histidine kinase CiaH Regulator
  RDV54_RS01775 (RDV54_01775) - 337907..338194 (-) 288 WP_001145221.1 DUF3270 domain-containing protein -
  RDV54_RS01780 (RDV54_01780) - 338334..339263 (+) 930 WP_000411171.1 peptidase U32 family protein -
  RDV54_RS01785 (RDV54_01785) - 339464..341914 (+) 2451 WP_000848734.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50706.41 Da        Isoelectric Point: 8.8716

>NTDB_id=874465 RDV54_RS01770 WP_000491799.1 336539..337873(+) (ciaH) [Streptococcus mitis strain LMG 14557]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDTSKTEIKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVIVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAIKYTEEDGEIDFMISATDRNLYLLVSDNGVGISAEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKVAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=874465 RDV54_RS01770 WP_000491799.1 336539..337873(+) (ciaH) [Streptococcus mitis strain LMG 14557]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGTAACTTTGGTGTATTCACTCTGAT
TTTCTCTACCATGACTCTGATTATTTTGCAGGTCATGCACTCGAGTCTTTATACTTCGGTGGATGATAAGCTTCATGGAC
TAAGTGAAAATCCTCAAGCAGTTATTCAGCTTGCTGTAAATAGGGCAACAGAAGAGATTAAAGATTTAGAGAATGCCGCT
ACAGATACTAGCAAGACTGAGATAAAACCCAATGTCAGTTCCAACACAGAAGTCATTCTTTTTGATAAGAATTTTACCCA
GCTCCTTTCTGGAAATCGATTTTTGGGATTGGATAAGATTAAGTTAGAGAAAAAAGAACTAGGACATATCTATCAGATTC
AGGTTTTTAATAGCTATGGACAAGAAGAAATCTATCGCATGATCTTGATGGAAACGAATATCAGTTCGGTTTCAACCAAT
ATCAAGTATGCAGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGATTGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTCGGCCCCTGCTTGAGAGCA
TGCAGAAGCAACAGTCCTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTTGCAGTTTTGCAAAATCGTTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCAACCATTATGGATGTGAGCGAAAGCATTGCGTCTAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTGACGACAAACTTGCTGAACTTAGCTCGTAGAGATGATGGGATTAAGCCGGAACTTGCAGAAGTTCCAACCA
GTTTTTTCAATACGACTTTCACAAACTATGAGATGATTGCTTCTGAAAATGACCGTGTCTTTCGTTTTGAAAATCGGATC
CATCGAACGATTGTCACGGATCAACTTCTTTTGAAACAACTGATGACCATCTTATTTGATAATGCCATCAAATATACTGA
GGAGGATGGTGAAATTGATTTTATGATTTCAGCGACTGATCGTAATCTGTATTTACTTGTTTCTGACAATGGAGTCGGTA
TTTCCGCAGAAGATAAGAAGAAAATATTTGACCGCTTTTATCGAGTGGACAAGGCTAGAACCCGCCAAAAAGGTGGTTTT
GGTTTAGGTTTATCCCTAGCCAAGCAAATTGTAGATGCCCTAAAAGGAACCATTACTGTTAAAGATAATAAACCAAAGGG
AACAATCTTTGAAGTGAAGGTAGCCATCCACACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

96.171

100

0.962
  ciaH Streptococcus pneumoniae D39

96.171

100

0.962
  ciaH Streptococcus pneumoniae R6

96.171

100

0.962
  ciaH Streptococcus pneumoniae TIGR4

96.171

100

0.962
  ciaH Streptococcus mutans UA159

55.402

97.973

0.543