Detailed information NTG0863869

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: Q7626_RS02385
• Genome accession: NZ_CP131707
• Coordinates: 477110..479263 (-)
• Length: 717 a.a.
• NCBI ID: WP_000205169.1
• Uniprot ID: A0A0E9GYL6
• Organism: Streptococcus pneumoniae strain 2018C08-270
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 472110..484263

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7626_RS02355 (Q7626_02350)	-	472442..472771 (-)	330	WP_000132572.1	hypothetical protein	-
Q7626_RS02360 (Q7626_02355)	-	473048..473386 (+)	339	WP_000876675.1	LytTR family DNA-binding domain-containing protein	-
Q7626_RS02365 (Q7626_02360)	comE/blpR	473391..474128 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
Q7626_RS02370 (Q7626_02365)	-	474142..475482 (+)	1341	WP_001017636.1	sensor histidine kinase	-
Q7626_RS02375 (Q7626_02370)	blpC	475553..475681 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
Q7626_RS02380 (Q7626_02375)	-	475738..477099 (-)	1362	WP_001069075.1	bacteriocin secretion accessory protein	-
Q7626_RS02385 (Q7626_02380)	comA/nlmT	477110..479263 (-)	2154	WP_000205169.1	peptide cleavage/export ABC transporter BlpA	Regulator
Q7626_RS02390 (Q7626_02385)	-	479544..479747 (+)	204	WP_001093272.1	bacteriocin class II family protein	-
Q7626_RS02395 (Q7626_02390)	-	480065..480268 (+)	204	WP_000411016.1	hypothetical protein	-
Q7626_RS02400 (Q7626_02395)	-	481271..482060 (+)	790	Protein_471	IS5 family transposase	-
Q7626_RS02405 (Q7626_02400)	blpM	482210..482464 (+)	255	WP_000379879.1	two-peptide bacteriocin subunit BlpM	-
Q7626_RS02410 (Q7626_02405)	blpN	482480..482683 (+)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
Q7626_RS02415 (Q7626_02410)	cipB	482927..483076 (+)	150	WP_001818346.1	bacteriocin-like peptide BlpO	Regulator
Q7626_RS02420 (Q7626_02415)	-	483180..483299 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80829.82 Da
• Isoelectric Point: 7.6798

>NTDB_id=863869 Q7626_RS02385 WP_000205169.1 477110..479263(-) (comA/nlmT) [Streptococcus pneumoniae strain 2018C08-270]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLVIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLISIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWFGAQLVMSSKISIGQLITFNTLFSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide

• Length: 2154 bp

>NTDB_id=863869 Q7626_RS02385 WP_000205169.1 477110..479263(-) (comA/nlmT) [Streptococcus pneumoniae strain 2018C08-270]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGGCCTGTTCAAGCAGATAAAACTCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGGTTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTTCTTA
TTATCTCCAAGGAATCTTAGATGAATACATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTCTCCAGAGATTATCTCCTAACCGTTCTGAGCCAGAGATTAAGCATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCCATGTCTTTCTTTGCGACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTCCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGCGTCTTACTGGCACAAAACCCTAATCTCTTCCTTCTTTCTCTTATTTCTATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAGCCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTGGAAAAATCCTTTAAGCTCAGTAAATATTCTATTTTACAAACAAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGTTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTTTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTTG
CTAATAACCGTTTGAACGAAGTCTATCTAGTCGAATCTGAATTTCAAGTTCAAGAAAACCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTTAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCCTACAAAGGACATATTTCCATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCACAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAACTTAACTTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAGAGCTTGTGAATTAGCTGAAATTCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCTGGTCTATCAGGAGGACAAAAGCAACGAATAGCCCTCGCTCGTGCTCTTTTAACTAAATCTCCT
GTTTTAATACTAGACGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAGGTTATAGATAATCTTATGTCTCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACCAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTATTCAATAAATAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (169-438)

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A0E9GYL6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	71.748	99.721	0.715
comA	Streptococcus mitis NCTC 12261	66.48	99.442	0.661
comA	Streptococcus pneumoniae Rx1	65.919	99.442	0.656
comA	Streptococcus pneumoniae R6	65.919	99.442	0.656
comA	Streptococcus pneumoniae D39	65.919	99.442	0.656
comA	Streptococcus mitis SK321	65.919	99.442	0.656
comA	Streptococcus gordonii str. Challis substr. CH1	65.181	100	0.653
comA	Streptococcus pneumoniae TIGR4	65.638	99.442	0.653