Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   WFE12_RS21755 Genome accession   NZ_CP147877
Coordinates   4148978..4150180 (-) Length   400 a.a.
NCBI ID   WP_009969578.1    Uniprot ID   P39668
Organism   Bacillus subtilis subsp. subtilis str. 168     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 4143978..4155180
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WFE12_RS21730 rocE 4144086..4145489 (-) 1404 WP_003242721.1 amino acid permease -
  WFE12_RS21735 rocD 4145712..4146917 (-) 1206 WP_003242970.1 ornithine aminotransferase -
  WFE12_RS21740 rocR 4147158..4148543 (+) 1386 WP_003244510.1 arginine utilization regulatory protein RocR -
  WFE12_RS21745 - 4148525..4148713 (-) 189 Protein_4231 ATP-binding protein -
  WFE12_RS21750 - 4148830..4148958 (-) 129 WP_003242634.1 hypothetical protein -
  WFE12_RS21755 htrA 4148978..4150180 (-) 1203 WP_009969578.1 serine protease HtrC Regulator
  WFE12_RS21760 vicX 4150262..4151056 (-) 795 WP_003242676.1 MBL fold metallo-hydrolase Regulator
  WFE12_RS21765 walI 4151078..4151920 (-) 843 WP_003244037.1 WalRK two-component regulatory system regulator WalI -
  WFE12_RS21770 walH 4151907..4153274 (-) 1368 WP_003242498.1 WalRK two-component regulatory system regulator WalH -
  WFE12_RS21775 walK 4153264..4155099 (-) 1836 WP_009968432.1 cell wall metabolism sensor histidine kinase WalK -

Sequence

Protein


Download         Length: 400 a.a.        Molecular weight: 42788.56 Da        Isoelectric Point: 5.3354

>NTDB_id=863366 WFE12_RS21755 WP_009969578.1 4148978..4150180(-) (htrA) [Bacillus subtilis subsp. subtilis str. 168]
MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPYLSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTK
IVSNMSPAVVGVVNIQKSDIWGESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL
AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVDSNGDGQPDWNAEVLQTDAAINP
GNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPSKLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPK
NVTNGAVVMGVDAFSPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKLSSADQLGS

Nucleotide


Download         Length: 1203 bp        

>NTDB_id=863366 WFE12_RS21755 WP_009969578.1 4148978..4150180(-) (htrA) [Bacillus subtilis subsp. subtilis str. 168]
ATGGTGGATTACGAACGTGAGGAAGAACATACTACTCCTGAACAGCCAAAGAGAAGCAAAAAAGGATATTTTCTTTCGAG
TCTGATTGGCGTGATTGTCGGTGCCGTATTAATGGCGTTTATCATGCCGTACCTTTCAAATGAAGGGCTGGATACAGGCG
CCTTAGATCAGCAGCAAAACAACAATGGCCGGGAATCAATCAGGACGGTGAATGTCAGTGTCAACAATGCCGTCACCAAG
ATTGTCAGCAATATGTCGCCCGCCGTTGTCGGTGTTGTGAACATCCAAAAATCAGATATTTGGGGAGAGAGCGGCGAGGC
TGGGAGCGGCTCTGGCGTCATCTATAAGAAAAATGACCATTCCGCTTATGTCGTGACCAACCATCATGTCATCGAAGGCG
CTTCCCAAATTGAAATCAGCTTGAAAGACGGCTCACGTGTATCAGCTGATCTTGTCGGCAGCGACCAGCTGATGGACCTT
GCCGTTTTACGGGTGAAAAGCGATAAGATTAAAGCAGTCGCTGATTTCGGAAATTCAGATAAAGTGAAGTCTGGGGAGCC
GGTTATTGCGATCGGGAACCCGTTAGGCCTTGAGTTTGCAGGCTCTGTCACACAAGGCGTCATCTCGGGTACGGAGAGGG
CGATCCCAGTAGATTCAAACGGTGATGGACAGCCTGACTGGAACGCTGAAGTCCTGCAAACAGATGCGGCCATTAACCCT
GGGAACAGCGGCGGCGCTTTGTTAAATATGGATGGGAAGGTCATTGGCATCAATTCAATGAAAATTGCCGAGTCAGCGGT
TGAAGGGATTGGCCTGTCCATTCCGTCTAAGCTCGTGATCCCTGTGATAGAGGATTTAGAGAGATACGGAAAGGTCAAAC
GCCCGTTCCTTGGCATTGAGATGAAATCGCTAAGTGACATCGCAAGCTATCATTGGGATGAAACATTAAAGCTTCCTAAG
AACGTCACCAATGGAGCGGTTGTGATGGGTGTAGACGCCTTTTCACCTGCCGGAAAAGCGGGGCTGAAGGAACTGGATGT
CATCACGGAATTTGACGGATACAAAGTAAATGATATTGTTGACCTGCGAAAACGGCTTTATCAGAAAAAAGTCGGTGACC
GGGTGAAGGTGAAGTTTTATCGCGGCGGAAAAGAAAAATCTGTTGATATCAAGCTGTCCTCCGCAGACCAATTAGGCAGT
TAA

Domains

Predicted by InterProScan.

PDZ domain (PDZ_2)

(295-392)

Trypsin-like peptidase domain (Trypsin_2)

(110-257)

Peptidase family M50 (Peptidase_M50)

(203-395)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P39668

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

43.577

99.25

0.433
  htrA Streptococcus gordonii str. Challis substr. CH1

41.294

100

0.415
  htrA Streptococcus mitis NCTC 12261

42.746

96.5

0.412
  htrA Streptococcus pneumoniae TIGR4

44.848

82.5

0.37
  htrA Streptococcus pneumoniae D39

44.848

82.5

0.37
  htrA Streptococcus pneumoniae Rx1

44.848

82.5

0.37
  htrA Streptococcus pneumoniae R6

44.848

82.5

0.37