Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   STYK_RS04190 Genome accession   NZ_AP024523
Coordinates   801856..802530 (+) Length   224 a.a.
NCBI ID   WP_000590639.1    Uniprot ID   A0A419RXM2
Organism   Streptococcus toyakuensis strain TP1632     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 796856..807530
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STYK_RS04165 (STYK_07670) - 796971..797669 (+) 699 WP_261805299.1 3-oxoacyl-ACP reductase -
  STYK_RS04170 (STYK_07680) - 797677..797820 (+) 144 Protein_769 NUDIX hydrolase -
  STYK_RS04175 (STYK_07690) - 797798..798667 (+) 870 WP_261805300.1 putative PEP-binding protein -
  STYK_RS04180 (STYK_07700) - 798642..799082 (+) 441 WP_203180577.1 ASCH domain-containing protein -
  STYK_RS04185 (STYK_07710) - 799204..801750 (+) 2547 WP_261805301.1 M1 family metallopeptidase -
  STYK_RS04190 (STYK_07720) ciaR 801856..802530 (+) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  STYK_RS04195 (STYK_07730) ciaH 802520..803854 (+) 1335 WP_078238304.1 two-component system sensor histidine kinase CiaH Regulator
  STYK_RS04200 (STYK_07740) - 803888..804175 (-) 288 WP_261017588.1 DUF3270 domain-containing protein -
  STYK_RS04205 (STYK_07750) - 804315..805244 (+) 930 WP_049550878.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=85739 STYK_RS04190 WP_000590639.1 801856..802530(+) (ciaR) [Streptococcus toyakuensis strain TP1632]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=85739 STYK_RS04190 WP_000590639.1 801856..802530(+) (ciaR) [Streptococcus toyakuensis strain TP1632]
ATGATAAAAATCTTATTAGTTGAGGATGACCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
CATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGCGTCTATGACTTGATTTTGCTCGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGAATTACGACCCCGGTTCTGATCATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTAGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGTAAGTTTAATGAGAACACCTTAACTTATGGAAATATTGTGG
TTAATCTGTCTACAAATACCGTTAAAGTCGAAGATACTCCTGTCGAATTGCTGGGGAAAGAATTTGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCGAAGACTCAGATTTTTGATCGTTTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTTGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A419RXM2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

88.839

100

0.888
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment