Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   STYK_RS04195 Genome accession   NZ_AP024523
Coordinates   802520..803854 (+) Length   444 a.a.
NCBI ID   WP_078238304.1    Uniprot ID   -
Organism   Streptococcus toyakuensis strain TP1632     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 797520..808854
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STYK_RS04170 (STYK_07680) - 797677..797820 (+) 144 Protein_769 NUDIX hydrolase -
  STYK_RS04175 (STYK_07690) - 797798..798667 (+) 870 WP_261805300.1 putative PEP-binding protein -
  STYK_RS04180 (STYK_07700) - 798642..799082 (+) 441 WP_203180577.1 ASCH domain-containing protein -
  STYK_RS04185 (STYK_07710) - 799204..801750 (+) 2547 WP_261805301.1 M1 family metallopeptidase -
  STYK_RS04190 (STYK_07720) ciaR 801856..802530 (+) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  STYK_RS04195 (STYK_07730) ciaH 802520..803854 (+) 1335 WP_078238304.1 two-component system sensor histidine kinase CiaH Regulator
  STYK_RS04200 (STYK_07740) - 803888..804175 (-) 288 WP_261017588.1 DUF3270 domain-containing protein -
  STYK_RS04205 (STYK_07750) - 804315..805244 (+) 930 WP_049550878.1 peptidase U32 family protein -
  STYK_RS04210 (STYK_07760) - 805444..807894 (+) 2451 WP_261805302.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50682.34 Da        Isoelectric Point: 8.8763

>NTDB_id=85740 STYK_RS04195 WP_078238304.1 802520..803854(+) (ciaH) [Streptococcus toyakuensis strain TP1632]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDTLHGLSNNPQAVIQLAVNRATEEIKDLENAA
TDASKTEIKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVIVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEFAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAIKYTEEDGEIDFMISATDRNLYLLVSDNGVGISAEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=85740 STYK_RS04195 WP_078238304.1 802520..803854(+) (ciaH) [Streptococcus toyakuensis strain TP1632]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTACTTTATCCGCAACTTTGGTGTCTTTACCCTGAT
TTTCTCTACCATGACCTTGATTATTTTGCAGGTCATGCACTCGAGCCTTTATACTTCGGTGGATGATACACTCCATGGCT
TGAGTAACAATCCTCAGGCAGTTATTCAGCTTGCGGTAAATAGGGCAACAGAAGAGATTAAAGATTTAGAGAATGCCGCT
ACAGATGCTAGCAAGACGGAGATAAAACCCAATGTTAGTTCAAATACAGAGGTCATTCTCTTTGATAAGAATTTTACCCA
ACTCCTTTCTGGAAACCGATTTTTGGGCTTGGATAAGATTAAGTTAGAGAAAAAAGAACTAGGCCATATCTATCAGATTC
AGGTTTTTAATAGCTATGGACAGGAAGAAATCTATCGCATGATCTTGATGGAAACGAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCGGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCCAGTCAAAAGCATGAGCAATTGATTGTGATTGT
GATGGCAAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGCA
TGCAGAAACAACAGTCCTTTGTGGAAAATGCTAGTCATGAGTTACGAACTCCACTTGCTGTTTTACAAAATCGTTTAGAG
ACCCTTTTCCGTAAGCCAGAAGCTACCATTATGGATGTGAGTGAAAGCATTGCATCGAGTTTGGAAGAGGTTCGAAATAT
GCGGTTTTTGACGACAAACTTGCTGAACTTAGCTCGGAGAGATGATGGTATTAAGCCGGAATTTGCTGAAGTTCCTACTA
GCTTTTTTAACACGACTTTCACAAACTATGAGATGATTGCTTCTGAAAATGACCGTGTCTTCCGTTTTGAAAATCGCATC
CATCGAACGATTGTCACAGATCAGCTTCTCTTGAAACAATTGATGACCATCCTATTTGATAATGCTATCAAATACACTGA
GGAGGATGGTGAAATTGATTTTATGATTTCAGCGACTGATCGTAATCTTTATTTGCTAGTTTCCGATAATGGAGTCGGTA
TCTCAGCAGAAGATAAGAAGAAAATTTTTGATCGTTTTTATCGAGTGGATAAGGCTAGAACCCGTCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCCCTAAAAGGAACCATTACTGTTAAAGATAATAAACCAAAGGG
AACAATTTTTGAAGTGAAGATTGCCATCCACACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

95.946

100

0.959
  ciaH Streptococcus pneumoniae D39

95.946

100

0.959
  ciaH Streptococcus pneumoniae R6

95.946

100

0.959
  ciaH Streptococcus pneumoniae TIGR4

95.946

100

0.959
  ciaH Streptococcus mutans UA159

55.402

97.973

0.543

Multiple sequence alignment