NTDB

Overview

Name	covR	Type	Regulator
Locus tag	LLA22_RS07660	Genome accession	NZ_CP128421
Coordinates	1527566..1528258 (-)	Length	230 a.a.
NCBI ID	WP_015082645.1	Uniprot ID	A0AAJ6N309
Organism	Lactococcus cremoris strain A.2.2
Function	repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1522566..1533258

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLA22_RS07640 (LLA22_07685)	murD	1522710..1524059 (-)	1350	WP_015082642.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
LLA22_RS07645 (LLA22_07690)	-	1524228..1524569 (-)	342	WP_011676628.1	P-II family nitrogen regulator	-
LLA22_RS07650 (LLA22_07695)	-	1524654..1525895 (-)	1242	WP_015082643.1	ammonium transporter	-
LLA22_RS07655 (LLA22_07700)	covS	1526081..1527553 (-)	1473	WP_021211938.1	HAMP domain-containing histidine kinase	Regulator
LLA22_RS07660 (LLA22_07705)	covR	1527566..1528258 (-)	693	WP_015082645.1	response regulator transcription factor	Regulator
LLA22_RS07665 (LLA22_07710)	-	1528414..1528944 (-)	531	WP_011834860.1	DUF177 domain-containing protein	-
LLA22_RS07670 (LLA22_07715)	-	1529077..1529322 (-)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLA22_RS07675 (LLA22_07720)	-	1529646..1530008 (-)	363	Protein_1493	TIGR02328 family protein	-
LLA22_RS07680 (LLA22_07725)	-	1530156..1530707 (+)	552	WP_021214392.1	Ltp family lipoprotein	-
LLA22_RS07685 (LLA22_07730)	-	1530815..1531585 (+)	771	WP_015082647.1	hypothetical protein	-
LLA22_RS07690 (LLA22_07735)	-	1531746..1532819 (-)	1074	WP_011676639.1	carbamoyl phosphate synthase small subunit	-

Sequence

Protein

Download Length: 230 a.a. Molecular weight: 26668.36 Da Isoelectric Point: 5.1313

                                >NTDB_id=847423 LLA22_RS07660 WP_015082645.1 1527566..1528258(-) (covR) [Lactococcus cremoris strain A.2.2]

MASKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM

TARDSTMERVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE

YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

Download Length: 693 bp

                                >NTDB_id=847423 LLA22_RS07660 WP_015082645.1 1527566..1528258(-) (covR) [Lactococcus cremoris strain A.2.2]

ATGGCATCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCTCGTTTCGTCTCATTAGAATTAGAGCATGAAGG

CTATGCCACTGAGATTAAAGATAACGGACGTTCTGGGCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG

ATTTGATGCTTCCTGAACTTGATGGTTTTGAAGTTGCCCGCCGTTTGCGCAAAGAAAAAGATACTCCAATTATTATGATG

ACCGCGCGTGATTCAACAATGGAACGTGTTGCCGGTCTTGATATTGGAGCAGATGATTATATTACTAAGCCTTTTGCGAT

TGAAGAACTTTTGGCTCGTGTTCGTGCATTCTTCCGTCGTGAAGAACATGGTCATGCTGTAGAACGTGCTGAAAACACTT

CTTTTCGTGATCTTGTAATTGACAAAACAAATCGTACCGTTCACCGCGGTAAAAAAGTAATTGATTTGACGCGTCGTGAA

TACGATCTTCTTTTGACGTTGATGCAAAATGTTGGGGATGTTGTCACTCGCGAACATTTAGTTTCACAAGTTTGGGGATA

TGAAGAAGGAACGGAAACAAATGTTGTTGATGTATATATCCGCTATCTTAGAAATAAAATTGATGTTGAAGGACAAGACA

GCTATATTCAAACCGTTCGTGGTTTGGGTTATGTGATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)

Response regulator receiver domain (Response_reg)

(6-115)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.13	100	0.991
covR	Streptococcus salivarius strain HSISS4	67.982	99.13	0.674
vicR	Streptococcus mutans UA159	45.455	100	0.457
micA	Streptococcus pneumoniae Cp1015	43.043	100	0.43
ciaR	Streptococcus mutans UA159	37.168	98.261	0.365

Detailed information NTG0847423