Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   QSV38_RS02870 Genome accession   NZ_CP128410
Coordinates   545815..546519 (-) Length   234 a.a.
NCBI ID   WP_024391260.1    Uniprot ID   A0A9X4MIJ1
Organism   Streptococcus parasuis strain 7500     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 510943..547570 545815..546519 within 0


Gene organization within MGE regions


Location: 510943..547570
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QSV38_RS02670 (QSV38_02670) - 510943..511887 (-) 945 WP_277836751.1 bifunctional oligoribonuclease/PAP phosphatase NrnA -
  QSV38_RS02675 (QSV38_02675) - 511982..512443 (+) 462 WP_217374881.1 flavodoxin -
  QSV38_RS02680 (QSV38_02680) rpsN 512619..512849 (+) 231 WP_254451638.1 30S ribosomal protein S14 -
  QSV38_RS02685 (QSV38_02685) - 512931..513206 (+) 276 WP_130554325.1 chorismate mutase -
  QSV38_RS02690 (QSV38_02690) - 513199..514383 (+) 1185 WP_277843328.1 chloride channel protein -
  QSV38_RS02695 (QSV38_02695) - 514569..514829 (-) 261 WP_289649094.1 hypothetical protein -
  QSV38_RS02700 (QSV38_02700) - 514864..515052 (-) 189 Protein_536 PTS system mannose/fructose/sorbose family transporter subunit IID -
  QSV38_RS02705 (QSV38_02705) - 515232..515381 (+) 150 WP_274504714.1 hypothetical protein -
  QSV38_RS02710 (QSV38_02710) - 515383..515709 (+) 327 WP_289649367.1 hypothetical protein -
  QSV38_RS02715 (QSV38_02715) - 515847..516674 (+) 828 WP_289649095.1 site-specific integrase -
  QSV38_RS02725 (QSV38_02725) - 516846..517520 (-) 675 WP_217375147.1 hydrolase -
  QSV38_RS02730 (QSV38_02730) - 517554..519299 (-) 1746 WP_289649096.1 ABC transporter ATP-binding protein -
  QSV38_RS02735 (QSV38_02735) - 519289..521028 (-) 1740 WP_217374837.1 ABC transporter transmembrane domain-containing protein -
  QSV38_RS02740 (QSV38_02740) rplS 521301..521648 (-) 348 WP_011921928.1 50S ribosomal protein L19 -
  QSV38_RS02745 (QSV38_02745) sodA 521850..522455 (-) 606 WP_217374836.1 superoxide dismutase -
  QSV38_RS02750 (QSV38_02750) holA 522532..523563 (-) 1032 WP_277843315.1 DNA polymerase III subunit delta -
  QSV38_RS02755 (QSV38_02755) comEC/celB 523627..525864 (-) 2238 WP_277843313.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  QSV38_RS02760 (QSV38_02760) - 525848..526525 (-) 678 WP_274504678.1 helix-hairpin-helix domain-containing protein -
  QSV38_RS02765 (QSV38_02765) - 526591..527334 (-) 744 WP_289649115.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  QSV38_RS02770 (QSV38_02770) - 527426..528175 (+) 750 WP_130554335.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  QSV38_RS02775 (QSV38_02775) - 528165..528437 (+) 273 WP_105127437.1 GIY-YIG nuclease family protein -
  QSV38_RS02780 (QSV38_02780) - 528455..529066 (-) 612 WP_289649117.1 NAD(P)H-dependent oxidoreductase -
  QSV38_RS02785 (QSV38_02785) - 529187..529593 (-) 407 Protein_552 GNAT family N-acetyltransferase -
  QSV38_RS02790 (QSV38_02790) - 529705..530307 (-) 603 WP_289649118.1 DUF1648 domain-containing protein -
  QSV38_RS02795 (QSV38_02795) - 530294..530572 (-) 279 WP_105136884.1 autorepressor SdpR family transcription factor -
  QSV38_RS02800 (QSV38_02800) - 530719..532344 (-) 1626 WP_277836759.1 DEAD/DEAH box helicase -
  QSV38_RS02805 (QSV38_02805) - 532630..533013 (-) 384 WP_217374827.1 PH domain-containing protein -
  QSV38_RS02810 (QSV38_02810) - 533208..533473 (-) 266 Protein_557 16S rRNA pseudouridine(516) synthase -
  QSV38_RS02815 (QSV38_02815) - 533499..534167 (-) 669 WP_277843299.1 hypothetical protein -
  QSV38_RS02820 (QSV38_02820) - 534169..535713 (-) 1545 WP_277843297.1 peptide chain release factor 3 -
  QSV38_RS02825 (QSV38_02825) murF 535884..537248 (-) 1365 WP_277843295.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
  QSV38_RS02830 (QSV38_02830) - 537303..537971 (-) 669 WP_277843294.1 ABC transporter ATP-binding protein -
  QSV38_RS02835 (QSV38_02835) - 537981..539057 (-) 1077 WP_289649119.1 ABC transporter permease -
  QSV38_RS02840 (QSV38_02840) - 539059..539439 (-) 381 WP_172025425.1 OsmC family protein -
  QSV38_RS02845 (QSV38_02845) - 539552..540598 (-) 1047 WP_277836762.1 D-alanine--D-alanine ligase -
  QSV38_RS02850 (QSV38_02850) recR 540707..541303 (-) 597 WP_172036408.1 recombination mediator RecR -
  QSV38_RS02855 (QSV38_02855) pbp2b 541312..543387 (-) 2076 WP_277843290.1 penicillin-binding protein PBP2B -
  QSV38_RS02860 (QSV38_02860) vicX 543663..544466 (-) 804 WP_217374822.1 MBL fold metallo-hydrolase Regulator
  QSV38_RS02865 (QSV38_02865) micB 544473..545822 (-) 1350 WP_217469406.1 cell wall metabolism sensor histidine kinase VicK Regulator
  QSV38_RS02870 (QSV38_02870) micA 545815..546519 (-) 705 WP_024391260.1 response regulator YycF Regulator
  QSV38_RS02875 (QSV38_02875) - 546809..547570 (+) 762 WP_130554350.1 amino acid ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26727.72 Da        Isoelectric Point: 4.8061

>NTDB_id=847300 QSV38_RS02870 WP_024391260.1 545815..546519(-) (micA) [Streptococcus parasuis strain 7500]
MKKILIVDDEKPISDIIKFNMTREGYEVVTAFDGREALDIFEAEFPDIVILDLMLPEIDGLEVARTIRKTSNVPILMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRSELAETQGAVESSGTPELVIGDLVIVPDAFVAKKHGKELELT
HREFELLYHLAKHIGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYFIKAYD

Nucleotide


Download         Length: 705 bp        

>NTDB_id=847300 QSV38_RS02870 WP_024391260.1 545815..546519(-) (micA) [Streptococcus parasuis strain 7500]
ATGAAGAAAATTTTAATTGTTGATGATGAGAAACCAATCTCGGATATTATTAAGTTCAATATGACACGTGAAGGATATGA
GGTAGTTACTGCGTTTGATGGACGTGAGGCGCTTGATATTTTTGAAGCAGAGTTTCCAGACATTGTTATTTTAGATTTAA
TGCTTCCAGAAATAGATGGATTAGAAGTAGCACGGACGATTCGAAAAACAAGTAATGTTCCTATTTTAATGTTGTCAGCT
AAAGATAGTGAGTTTGATAAAGTTATTGGGCTTGAAATTGGTGCGGATGACTATGTGACAAAGCCATTCTCAAACCGTGA
ATTACAGGCACGTGTAAAAGCTCTTCTTCGTCGAAGTGAATTGGCTGAGACGCAAGGAGCAGTTGAATCCTCTGGTACTC
CAGAATTGGTAATCGGTGATTTGGTAATTGTTCCAGATGCTTTTGTAGCTAAGAAACATGGAAAAGAACTTGAACTAACA
CACCGTGAATTTGAATTATTGTATCATTTGGCCAAGCACATTGGGCAAGTCATGACGCGAGAGCATCTACTTGAGACTGT
TTGGGGATATGATTATTTTGGAGATGTACGTACTGTGGACGTGACAGTTCGACGCTTGCGTGAAAAAATTGAAGACACTC
CAAGTCGTCCGGAATACATCTTGACACGCAGGGGAGTAGGTTATTTTATAAAAGCTTATGATTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

84.416

98.718

0.833
  vicR Streptococcus mutans UA159

80.851

100

0.812
  covR Streptococcus salivarius strain HSISS4

43.29

98.718

0.427
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.043

98.291

0.423
  scnR Streptococcus mutans UA159

36.709

100

0.372