Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraS   Type   Regulator
Locus tag   ST1232TP_RS09785 Genome accession   NZ_AP024311
Coordinates   1995780..1996823 (-) Length   347 a.a.
NCBI ID   WP_001017131.1    Uniprot ID   A0A0D1IMN4
Organism   Staphylococcus aureus strain THI2018-120     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1990780..2001823
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ST1232TP_RS09755 (THI2018120TP_18440) - 1991201..1992457 (-) 1257 WP_001793428.1 aminopeptidase -
  ST1232TP_RS09760 (THI2018120TP_18450) - 1992460..1992660 (-) 201 WP_000180460.1 DUF1128 family protein -
  ST1232TP_RS09765 (THI2018120TP_18460) - 1992807..1993271 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  ST1232TP_RS09770 (THI2018120TP_18470) - 1993278..1993553 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  ST1232TP_RS09775 (THI2018120TP_18480) - 1993831..1995048 (+) 1218 WP_000037081.1 YihY/virulence factor BrkB family protein -
  ST1232TP_RS09780 (THI2018120TP_18490) vraR 1995161..1995790 (-) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  ST1232TP_RS09785 (THI2018120TP_18500) vraS 1995780..1996823 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  ST1232TP_RS09790 (THI2018120TP_18510) liaF 1996820..1997521 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  ST1232TP_RS09795 (THI2018120TP_18520) - 1997536..1997922 (-) 387 WP_001110182.1 hypothetical protein -
  ST1232TP_RS09800 (THI2018120TP_18530) map 1998139..1998897 (-) 759 WP_000636145.1 type I methionyl aminopeptidase -
  ST1232TP_RS09805 (THI2018120TP_18550) - 1999481..2000467 (+) 987 WP_000999712.1 aromatic acid exporter family protein -
  ST1232TP_RS09810 (THI2018120TP_18560) - 2000656..2001069 (-) 414 WP_025174370.1 hypothetical protein -
  ST1232TP_RS09815 - 2001098..2001208 (-) 111 WP_014937049.1 hypothetical protein -

Sequence

Protein


Download         Length: 347 a.a.        Molecular weight: 40044.52 Da        Isoelectric Point: 6.0577

>NTDB_id=84634 ST1232TP_RS09785 WP_001017131.1 1995780..1996823(-) (vraS) [Staphylococcus aureus strain THI2018-120]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide


Download         Length: 1044 bp        

>NTDB_id=84634 ST1232TP_RS09785 WP_001017131.1 1995780..1996823(-) (vraS) [Staphylococcus aureus strain THI2018-120]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(249-340)

Histidine kinase (HisKA_3)

(147-210)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0D1IMN4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraS Staphylococcus aureus N315

100

100

1

Multiple sequence alignment