Detailed information NTG0840397

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: VKP39_RS02060
• Genome accession: NZ_CP142353
• Coordinates: 390137..392290 (-)
• Length: 717 a.a.
• NCBI ID: WP_109828899.1
• Uniprot ID: C7DQV2
• Organism: Streptococcus pyogenes strain D641
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 385137..397290

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP39_RS02040 (VKP39_02040)	comE/blpR	386328..387077 (+)	750	WP_030127040.1	response regulator transcription factor	Regulator
VKP39_RS02045 (VKP39_02045)	-	387078..388412 (+)	1335	WP_014635339.1	sensor histidine kinase	-
VKP39_RS02050 (VKP39_02050)	-	388560..388685 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
VKP39_RS02055 (VKP39_02055)	-	388762..390126 (-)	1365	WP_014635340.1	bacteriocin secretion accessory protein	-
VKP39_RS02060 (VKP39_02060)	comA/nlmT	390137..392290 (-)	2154	WP_109828899.1	peptide cleavage/export ABC transporter	Regulator
VKP39_RS02065 (VKP39_02065)	-	392742..393428 (+)	687	Protein_359	transposase	-
VKP39_RS02070 (VKP39_02070)	-	393616..393861 (+)	246	WP_002994504.1	Blp family class II bacteriocin	-
VKP39_RS02075 (VKP39_02075)	-	393876..394058 (+)	183	WP_002987564.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
VKP39_RS02080 (VKP39_02080)	-	394249..394935 (-)	687	Protein_362	transposase	-
VKP39_RS02085 (VKP39_02085)	-	395253..395480 (+)	228	WP_012560514.1	Blp family class II bacteriocin	-
VKP39_RS02090 (VKP39_02090)	-	395493..395693 (+)	201	WP_003060803.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
VKP39_RS02095 (VKP39_02095)	-	396054..396182 (+)	129	WP_002985724.1	hypothetical protein	-
VKP39_RS02100 (VKP39_02100)	-	396232..396513 (+)	282	WP_011054252.1	hypothetical protein	-
VKP39_RS02105 (VKP39_02105)	-	396707..397107 (+)	401	Protein_367	hypothetical protein	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80442.32 Da
• Isoelectric Point: 6.8674

>NTDB_id=840397 VKP39_RS02060 WP_109828899.1 390137..392290(-) (comA/nlmT) [Streptococcus pyogenes strain D641]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVVYQNKKNYLIIGDPDPTVNVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSCKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIETGSHQELMTKQGFYHHLFSG

Nucleotide

• Length: 2154 bp

>NTDB_id=840397 VKP39_RS02060 WP_109828899.1 390137..392290(-) (comA/nlmT) [Streptococcus pyogenes strain D641]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCGTCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACCCGACAGTAAATGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGATAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAT
GTTATTTTATCCTATATTCGTCATATTTTTGAGCTTCCCATGTCTTTCTTTGCAACACGTCGGACAGGAGAAATCATTTC
ACGGTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCTTTTAAGTTAAGTAAGTATTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTGTAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCGCTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAACAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTGGTTAA

Domains

Predicted by InterProScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-649)

3D structure

• AlphaFold DB: C7DQV2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.587	99.721	0.724
comA	Streptococcus mitis NCTC 12261	67.511	99.163	0.669
comA	Streptococcus mitis SK321	67.089	99.163	0.665
comA	Streptococcus pneumoniae Rx1	67.089	99.163	0.665
comA	Streptococcus pneumoniae D39	67.089	99.163	0.665
comA	Streptococcus pneumoniae R6	67.089	99.163	0.665
comA	Streptococcus pneumoniae TIGR4	66.807	99.163	0.662
comA	Streptococcus gordonii str. Challis substr. CH1	65.874	99.721	0.657