Detailed information NTG0840396

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: VKP39_RS02040
• Genome accession: NZ_CP142353
• Coordinates: 386328..387077 (+)
• Length: 249 a.a.
• NCBI ID: WP_030127040.1
• Uniprot ID: C7DQU7
• Organism: Streptococcus pyogenes strain D641
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 381328..392077

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP39_RS08665	-	381666..381977 (+)	312	WP_225793061.1	CPBP family intramembrane glutamic endopeptidase	-
VKP39_RS02015 (VKP39_02015)	-	382062..382190 (+)	129	WP_002994583.1	hypothetical protein	-
VKP39_RS02020 (VKP39_02020)	-	382588..382815 (+)	228	WP_028797129.1	Blp family class II bacteriocin	-
VKP39_RS02025 (VKP39_02025)	-	382864..383181 (+)	318	WP_002994587.1	hypothetical protein	-
VKP39_RS02030 (VKP39_02030)	-	383301..384385 (+)	1085	Protein_352	IS3 family transposase	-
VKP39_RS02035 (VKP39_02035)	-	384599..386093 (+)	1495	Protein_353	IS1182 family transposase	-
VKP39_RS02040 (VKP39_02040)	comE/blpR	386328..387077 (+)	750	WP_030127040.1	response regulator transcription factor	Regulator
VKP39_RS02045 (VKP39_02045)	-	387078..388412 (+)	1335	WP_014635339.1	sensor histidine kinase	-
VKP39_RS02050 (VKP39_02050)	-	388560..388685 (-)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
VKP39_RS02055 (VKP39_02055)	-	388762..390126 (-)	1365	WP_014635340.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29175.55 Da
• Isoelectric Point: 5.8302

>NTDB_id=840396 VKP39_RS02040 WP_030127040.1 386328..387077(+) (comE/blpR) [Streptococcus pyogenes strain D641]
MNIFVLEDDFLHQTRIEKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDIKGEDKKGMEIAVEIRNRD
PHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRIEKAITYVQDNQGKTLAEDSFVFINVKSQIQVPFSDLLY
IETSLIPHKLILYSTKQRVEFYGQLSEIVEQDDRLFQCHRSFVVNPYNISSIDRAERLVYLKGGLSCIVSRLKIRSLIKV
VEELHTKEK

Nucleotide

• Length: 750 bp

>NTDB_id=840396 VKP39_RS02040 WP_030127040.1 386328..387077(+) (comE/blpR) [Streptococcus pyogenes strain D641]
ATGAATATTTTTGTCTTAGAGGACGATTTTTTACATCAAACCAGAATTGAAAAAATTATTTATAAGATTTTGACTGATAA
TAAGTTGGAGGTTAACCACTTGGAAGTTTATGGTAAACCCAATCAGCTGCTTGAAGATATATCAGAGAGAGGAAGACATC
AGCTTTTTTTTCTTGACATTGACATTAAGGGAGAAGATAAAAAAGGAATGGAAATTGCTGTGGAGATTAGAAATAGAGAT
CCGCACGCAGTGATAGTTTTTGTGACCACACATTCAGAATTTATGCCGGTATCTTTTCAATACCAGGTTTCAGCTTTAGA
CTTTATTGACAAAGAGTTGCCAGAGGAGTTATTTAGTCATCGCATTGAAAAAGCTATAACTTATGTACAAGATAACCAAG
GAAAAACGTTAGCGGAGGATTCATTTGTTTTTATTAATGTAAAGTCCCAGATACAAGTCCCCTTTTCAGATTTGCTGTAT
ATTGAAACCTCACTAATTCCCCATAAACTCATTCTCTATTCTACTAAACAAAGAGTAGAATTTTATGGCCAATTATCAGA
AATTGTTGAGCAAGATGATCGATTATTTCAATGTCATCGTTCCTTTGTTGTTAATCCCTATAATATATCATCAATAGATA
GAGCCGAACGGTTAGTTTATTTAAAGGGGGGATTATCTTGTATTGTTTCGAGATTGAAAATACGATCATTAATAAAAGTA
GTAGAAGAGTTGCACACTAAGGAGAAATAG

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-119)

• LytTr DNA-binding domain (LytTR) (150-239)

3D structure

• AlphaFold DB: C7DQU7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.508	97.992	0.534
comE/comE2	Streptococcus gordonii strain NCTC7865	40.873	100	0.414
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	40.873	100	0.414
comE/comE1	Streptococcus equinus JB1	41.597	95.582	0.398
comE/comE2	Streptococcus equinus JB1	40.574	97.992	0.398
comE	Streptococcus mitis NCTC 12261	38.8	100	0.39
comE	Streptococcus mitis SK321	38.8	100	0.39
comE	Streptococcus pneumoniae TIGR4	38.4	100	0.386
comE	Streptococcus pneumoniae Rx1	38.4	100	0.386
comE	Streptococcus pneumoniae D39	38.4	100	0.386
comE	Streptococcus pneumoniae R6	38.4	100	0.386
comE	Streptococcus infantis strain Atu-4	38.095	100	0.386