Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   H7680_RS00355 Genome accession   NZ_AP023394
Coordinates   56711..57622 (+) Length   303 a.a.
NCBI ID   WP_003060893.1    Uniprot ID   A0AAE9U6L1
Organism   Streptococcus dysgalactiae subsp. equisimilis strain 159     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 45101..71029 56711..57622 within 0


Gene organization within MGE regions


Location: 45101..71029
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7680_RS00300 (SDSE159_00270) purM 45101..46129 (+) 1029 WP_003056406.1 phosphoribosylformylglycinamidine cyclo-ligase -
  H7680_RS00305 (SDSE159_00280) purN 46122..46676 (+) 555 WP_003056410.1 phosphoribosylglycinamide formyltransferase -
  H7680_RS00310 (SDSE159_00290) - 46783..47266 (+) 484 Protein_28 VanZ family protein -
  H7680_RS00315 (SDSE159_00300) purH 47285..48829 (+) 1545 WP_014611911.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase -
  H7680_RS00320 (SDSE159_00310) - 48909..50036 (-) 1128 WP_003055557.1 SH3 domain-containing protein -
  H7680_RS00325 (SDSE159_00320) purD 50319..51581 (+) 1263 WP_003055553.1 phosphoribosylamine--glycine ligase -
  H7680_RS00330 (SDSE159_00330) purE 52212..52700 (+) 489 WP_003055559.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  H7680_RS00335 (SDSE159_00340) purK 52687..53760 (+) 1074 WP_003055561.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  H7680_RS00340 (SDSE159_00350) - 53770..55026 (+) 1257 WP_003055555.1 DUF4041 domain-containing protein -
  H7680_RS00345 (SDSE159_00360) - 55019..55228 (+) 210 WP_014611912.1 hypothetical protein -
  H7680_RS00350 (SDSE159_00370) purB 55277..56569 (+) 1293 WP_003056595.1 adenylosuccinate lyase -
  H7680_RS00355 (SDSE159_00380) comR 56711..57622 (+) 912 WP_003060893.1 XRE family transcriptional regulator Regulator
  H7680_RS10365 comS 57709..57807 (+) 99 WP_014611913.1 quorum-sensing system DWW-type pheromone Regulator
  H7680_RS00360 (SDSE159_00390) ruvB 57841..58839 (+) 999 WP_003059357.1 Holliday junction branch migration DNA helicase RuvB -
  H7680_RS00365 (SDSE159_00400) - 58974..59405 (+) 432 WP_003059365.1 low molecular weight protein-tyrosine-phosphatase -
  H7680_RS00370 (SDSE159_00410) - 59434..59835 (+) 402 WP_003049089.1 MORN repeat-containing protein -
  H7680_RS00375 (SDSE159_00420) - 59832..61607 (+) 1776 WP_003059359.1 acyltransferase family protein -
  H7680_RS00380 (SDSE159_00430) adhE 61928..64570 (+) 2643 WP_003059363.1 bifunctional acetaldehyde-CoA/alcohol dehydrogenase -
  H7680_RS00385 (SDSE159_00440) adhP 64863..65879 (+) 1017 WP_003059355.1 alcohol dehydrogenase AdhP -
  H7680_RS00390 (SDSE159_00460) thrC 66071..67555 (+) 1485 WP_003059350.1 threonine synthase -
  H7680_RS00395 (SDSE159_00470) - 67595..68884 (+) 1290 WP_014611915.1 MATE family efflux transporter -
  H7680_RS00400 (SDSE159_00480) - 68954..69976 (-) 1023 WP_184006755.1 IS30 family transposase -
  H7680_RS00405 (SDSE159_00490) - 70052..71029 (-) 978 WP_014611916.1 IS30 family transposase -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35995.62 Da        Isoelectric Point: 4.7392

>NTDB_id=83031 H7680_RS00355 WP_003060893.1 56711..57622(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain 159]
MLEHFGEKVRGLRLEKGISREELCGDEAELSVRQLARIELGQSIPSLAKVIFIAKALEVSVGYLTDGANLELPKRYKELK
YLILRTPTYMDDRKLQVRESQFDEIFENYYDQLPEEEKIAIDIIQAKFEVYQTGDINFGFNILKEFLPQLKKKTVYNLNE
LLLIDLYLIILVVSNFTNDLFDEEFYKEITERILEQHQYLLLEDLFLLNNILLSCADTSIRLKMFERLKDTLQLSHFIMS
TIQDFQRMPMYCMYEWKLSIFYLKDIKRAETYFSQSLTFTQMTNDSYLAQKLQKEWDKDIHPS

Nucleotide


Download         Length: 912 bp        

>NTDB_id=83031 H7680_RS00355 WP_003060893.1 56711..57622(+) (comR) [Streptococcus dysgalactiae subsp. equisimilis strain 159]
ATGTTAGAGCATTTTGGTGAAAAAGTGAGAGGATTAAGACTTGAGAAAGGGATTAGTCGAGAGGAATTGTGTGGAGATGA
GGCAGAATTGTCTGTTCGCCAGTTGGCGAGGATAGAGCTAGGTCAATCTATACCAAGTTTAGCGAAGGTTATTTTTATTG
CGAAAGCCTTAGAGGTCAGCGTCGGTTATTTGACGGATGGCGCTAACCTAGAACTCCCTAAACGATATAAAGAGTTAAAA
TATCTCATTTTAAGGACTCCGACTTATATGGACGATCGCAAATTACAGGTCCGGGAGTCTCAGTTTGATGAGATATTTGA
AAACTATTATGATCAATTGCCCGAGGAGGAAAAAATAGCGATTGATATTATCCAGGCAAAATTTGAAGTTTATCAGACAG
GTGATATTAATTTTGGTTTTAATATTTTAAAAGAATTTCTACCACAACTAAAAAAGAAAACGGTTTATAACTTAAATGAA
TTATTATTAATTGATTTATATTTAATTATTTTAGTTGTTTCTAACTTTACAAATGACCTATTTGATGAGGAATTTTATAA
AGAAATAACGGAGCGAATCTTAGAACAGCATCAATACCTGTTATTAGAAGATTTATTTCTATTAAATAATATTCTTTTAT
CTTGCGCAGATACTTCTATTCGTTTAAAAATGTTTGAACGACTAAAGGATACGTTACAACTCAGCCATTTTATTATGTCA
ACCATTCAAGATTTTCAGCGAATGCCCATGTATTGCATGTATGAATGGAAATTGTCTATCTTTTATTTAAAAGATATTAA
ACGAGCAGAAACTTATTTTAGTCAATCTCTCACGTTTACTCAAATGACTAATGATAGTTATTTGGCACAAAAGCTTCAAA
AAGAATGGGATAAGGATATTCATCCCTCTTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS315

83.389

99.34

0.828
  comR Streptococcus pyogenes MGAS8232

55.629

99.67

0.554
  comR Streptococcus mutans UA159

46.154

98.68

0.455
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

46.575

96.37

0.449
  comR Streptococcus suis P1/7

37.288

97.36

0.363
  comR Streptococcus suis 05ZYH33

37.288

97.36

0.363

Multiple sequence alignment