Detailed information NTG0083029

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: H7678_RS10585
• Genome accession: NZ_AP023393
• Coordinates: 2156288..2157511 (+)
• Length: 407 a.a.
• NCBI ID: WP_046177498.1
• Uniprot ID: A0A9X9SR06
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain 89
• Function: require for competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2154356..2155354	2156288..2157511	flank	934

Gene organization within MGE regions

Location: 2154356..2157511

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7678_RS10570 (SDSE89_20720)	-	2154356..2155354 (+)	999	WP_184010329.1	IS30 family transposase	-
H7678_RS10580 (SDSE89_20730)	rlmH	2155597..2156076 (-)	480	WP_003057960.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
H7678_RS10585 (SDSE89_20740)	htrA	2156288..2157511 (+)	1224	WP_046177498.1	trypsin-like peptidase domain-containing protein	Regulator

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42772.43 Da
• Isoelectric Point: 7.3920

>NTDB_id=83029 H7678_RS10585 WP_046177498.1 2156288..2157511(+) (htrA) [Streptococcus dysgalactiae subsp. equisimilis strain 89]
MPSMKHILKSLSVLLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRLKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=83029 H7678_RS10585 WP_046177498.1 2156288..2157511(+) (htrA) [Streptococcus dysgalactiae subsp. equisimilis strain 89]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTGTTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTTAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTGGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTTAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGGATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGACTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAATCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGATGTTATTAAAATTATTAAACAGCTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGATTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

• PDZ domain (PDZ_2) (301-396)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.634	99.263	0.612
htrA	Streptococcus gordonii str. Challis substr. CH1	55.224	98.771	0.545
htrA	Streptococcus mitis NCTC 12261	53.171	100	0.536
htrA	Streptococcus pneumoniae Rx1	52.927	100	0.533
htrA	Streptococcus pneumoniae D39	52.927	100	0.533
htrA	Streptococcus pneumoniae R6	52.927	100	0.533
htrA	Streptococcus pneumoniae TIGR4	52.927	100	0.533