Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   KUN2590_RS00685 Genome accession   NZ_AP023387
Coordinates   105728..106681 (+) Length   317 a.a.
NCBI ID   WP_011054117.1    Uniprot ID   A0A5S4TQH7
Organism   Streptococcus pyogenes strain NIH34     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 100728..111681
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KUN2590_RS00645 (SPNIH34_00790) - 101555..101920 (+) 366 WP_002986560.1 DUF1033 family protein -
  KUN2590_RS00650 (SPNIH34_00800) comYA 102013..102951 (+) 939 WP_011054114.1 competence type IV pilus ATPase ComGA Machinery gene
  KUN2590_RS00655 (SPNIH34_00810) comYB 102887..103921 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  KUN2590_RS00660 (SPNIH34_00820) comYC 103923..104249 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  KUN2590_RS00665 (SPNIH34_00830) comGD 104224..104652 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  KUN2590_RS00670 (SPNIH34_00840) comGE 104609..104893 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  KUN2590_RS00675 (SPNIH34_00850) comYF 104886..105320 (+) 435 WP_002992738.1 competence type IV pilus minor pilin ComGF Machinery gene
  KUN2590_RS00680 (SPNIH34_00860) comGG 105304..105630 (+) 327 WP_010921801.1 competence type IV pilus minor pilin ComGG -
  KUN2590_RS00685 (SPNIH34_00870) comYH 105728..106681 (+) 954 WP_011054117.1 class I SAM-dependent methyltransferase Machinery gene
  KUN2590_RS00690 (SPNIH34_00880) - 106740..107936 (+) 1197 WP_010921803.1 acetate kinase -
  KUN2590_RS00695 (SPNIH34_00890) - 108122..108430 (+) 309 WP_011054118.1 hypothetical protein -
  KUN2590_RS00700 (SPNIH34_00900) proC 108513..109283 (-) 771 WP_002992745.1 pyrroline-5-carboxylate reductase -
  KUN2590_RS00705 (SPNIH34_00910) pepA 109331..110398 (-) 1068 WP_011054119.1 glutamyl aminopeptidase -
  KUN2590_RS00710 (SPNIH34_00920) - 110863..111147 (+) 285 WP_002992749.1 DUF4651 domain-containing protein -
  KUN2590_RS00715 (SPNIH34_00930) - 111144..111461 (+) 318 WP_002992751.1 thioredoxin family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 36027.22 Da        Isoelectric Point: 4.7205

>NTDB_id=82656 KUN2590_RS00685 WP_011054117.1 105728..106681(+) (comYH) [Streptococcus pyogenes strain NIH34]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLAPVNLLTSPQ
SQLLKQWLKDYAQVVALIMLPDSIFGHPSNAKSIIVLQKQIDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide


Download         Length: 954 bp        

>NTDB_id=82656 KUN2590_RS00685 WP_011054117.1 105728..106681(+) (comYH) [Streptococcus pyogenes strain NIH34]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACT
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAGATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCCAAACGATACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCACTTATTAA
TGGAACAGTCTTTAAAATACTTGAAAAAAGACGGTTTTGCGATTTTTCTGGCACCAGTCAATTTATTGACGAGCCCTCAG
AGCCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGGCCTTGATTATGCTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAATAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(68-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TQH7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA159

66.139

99.685

0.659
  comYH Streptococcus mutans UA140

65.823

99.685

0.656

Multiple sequence alignment