Detailed information NTG0818668

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAY70_RS00505
• Genome accession: NZ_CP123099
• Coordinates: 90885..91928 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IT-MSSA55
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 85885..96928

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAY70_RS00475 (QAY70_00475)	-	86314..86424 (+)	111	WP_001790257.1	hypothetical protein	-
QAY70_RS00480 (QAY70_00480)	-	86453..86866 (+)	414	WP_025173836.1	hypothetical protein	-
QAY70_RS00485 (QAY70_00485)	-	87297..88283 (-)	987	WP_000999714.1	FUSC family protein	-
QAY70_RS00490 (QAY70_00490)	map	88811..89569 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAY70_RS00495 (QAY70_00495)	-	89786..90172 (+)	387	WP_001110179.1	hypothetical protein	-
QAY70_RS00500 (QAY70_00500)	liaF	90187..90888 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAY70_RS00505 (QAY70_00505)	vraS	90885..91928 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAY70_RS00510 (QAY70_00510)	vraR	91918..92547 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
QAY70_RS00515 (QAY70_00515)	-	92659..93876 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
QAY70_RS00520 (QAY70_00520)	-	94154..94429 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QAY70_RS00525 (QAY70_00525)	-	94436..94900 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QAY70_RS00530 (QAY70_00530)	-	95047..95247 (+)	201	WP_000180460.1	DUF1128 family protein	-
QAY70_RS00535 (QAY70_00535)	-	95250..96506 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=818668 QAY70_RS00505 WP_001017131.1 90885..91928(+) (vraS) [Staphylococcus aureus strain IT-MSSA55]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=818668 QAY70_RS00505 WP_001017131.1 90885..91928(+) (vraS) [Staphylococcus aureus strain IT-MSSA55]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1