NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	P8P68_RS01480	Genome accession	NZ_CP121467
Coordinates	308898..309572 (+)	Length	224 a.a.
NCBI ID	WP_000590635.1	Uniprot ID	A0A139R176
Organism	Streptococcus sp. D7B5
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 303898..314572

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
P8P68_RS01455 (P8P68_01455)	-	303954..306494 (+)	2541	WP_001149142.1	M1 family metallopeptidase	-
P8P68_RS01460 (P8P68_01460)	-	306676..306960 (+)	285	WP_008283941.1	helix-turn-helix transcriptional regulator	-
P8P68_RS01465 (P8P68_01465)	-	307011..307337 (+)	327	WP_009013481.1	multidrug efflux SMR transporter	-
P8P68_RS01470 (P8P68_01470)	-	307352..308155 (+)	804	WP_000502735.1	SDR family NAD(P)-dependent oxidoreductase	-
P8P68_RS01475 (P8P68_01475)	-	308313..308767 (+)	455	Protein_287	hypothetical protein	-
P8P68_RS01480 (P8P68_01480)	ciaR	308898..309572 (+)	675	WP_000590635.1	two-component system response regulator CiaR	Regulator
P8P68_RS01485 (P8P68_01485)	ciaH	309562..310899 (+)	1338	WP_000482350.1	HAMP domain-containing sensor histidine kinase	Regulator
P8P68_RS01490 (P8P68_01490)	-	310964..311248 (-)	285	WP_001276161.1	DUF3270 domain-containing protein	-
P8P68_RS01495 (P8P68_01495)	-	311633..312688 (+)	1056	WP_000280281.1	ABC transporter permease	-
P8P68_RS01500 (P8P68_01500)	-	312702..313382 (+)	681	WP_278276029.1	ABC transporter ATP-binding protein	-
P8P68_RS01505 (P8P68_01505)	-	313510..314439 (+)	930	WP_125827729.1	peptidase U32 family protein	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25465.26 Da Isoelectric Point: 4.2660

                                >NTDB_id=812200 P8P68_RS01480 WP_000590635.1 308898..309572(+) (ciaR) [Streptococcus sp. D7B5]

MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDVVVNLSTNEVKVEDTPVELLGKEFELLVY

FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide

Download Length: 675 bp

                                >NTDB_id=812200 P8P68_RS01480 WP_000590635.1 308898..309572(+) (ciaR) [Streptococcus sp. D7B5]

ATGATTAAGATTTTACTAGTAGAAGACGACTTAGGGTTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT

TATGCAGGTTTTTGATGGAGAAGAAGGTCTCTATGAAGCTGAGAGTGGCGTCTATGATTTGATCTTGCTTGACCTTATGT

TGCCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAAGGAATCACGACACCAGTCCTTATCATGACCGCT

AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTACCTCACCAAACCTTTCTACCTAGAAGA

ACTCAAAATGCGGATTCAAGCCCTTCTCAAACGTTCAGGCAAGTTTAATGAAAACACCTTGACCTATGGGGATGTTGTCG

TCAATCTTTCAACGAATGAAGTGAAGGTGGAAGACACGCCTGTGGAACTACTCGGAAAAGAGTTTGAATTGTTGGTTTAC

TTCCTTCAAAATCAAAATGTCATTCTTCCCAAGACACAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACGAT

TTCTGTTGTAGAAGTCTATGTTTCAAAAGTTCGTAAGAAACTGAAGGGTACAGCCTTTGCTGAAAATCTTCAAACCTTGC

GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A139R176

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae TIGR4	97.321	100	0.973
ciaR	Streptococcus pneumoniae D39	97.321	100	0.973
ciaR	Streptococcus pneumoniae R6	97.321	100	0.973
ciaR	Streptococcus pneumoniae Rx1	97.321	100	0.973
ciaR	Streptococcus mutans UA159	87.5	100	0.875
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366

Detailed information NTG0812200