Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   P8P68_RS01485 Genome accession   NZ_CP121467
Coordinates   309562..310899 (+) Length   445 a.a.
NCBI ID   WP_000482350.1    Uniprot ID   K0ZJY4
Organism   Streptococcus sp. D7B5     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 304562..315899
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P8P68_RS01460 (P8P68_01460) - 306676..306960 (+) 285 WP_008283941.1 helix-turn-helix transcriptional regulator -
  P8P68_RS01465 (P8P68_01465) - 307011..307337 (+) 327 WP_009013481.1 multidrug efflux SMR transporter -
  P8P68_RS01470 (P8P68_01470) - 307352..308155 (+) 804 WP_000502735.1 SDR family NAD(P)-dependent oxidoreductase -
  P8P68_RS01475 (P8P68_01475) - 308313..308767 (+) 455 Protein_287 hypothetical protein -
  P8P68_RS01480 (P8P68_01480) ciaR 308898..309572 (+) 675 WP_000590635.1 two-component system response regulator CiaR Regulator
  P8P68_RS01485 (P8P68_01485) ciaH 309562..310899 (+) 1338 WP_000482350.1 HAMP domain-containing sensor histidine kinase Regulator
  P8P68_RS01490 (P8P68_01490) - 310964..311248 (-) 285 WP_001276161.1 DUF3270 domain-containing protein -
  P8P68_RS01495 (P8P68_01495) - 311633..312688 (+) 1056 WP_000280281.1 ABC transporter permease -
  P8P68_RS01500 (P8P68_01500) - 312702..313382 (+) 681 WP_278276029.1 ABC transporter ATP-binding protein -
  P8P68_RS01505 (P8P68_01505) - 313510..314439 (+) 930 WP_125827729.1 peptidase U32 family protein -
  P8P68_RS01510 (P8P68_01510) rpiA 314545..315228 (+) 684 WP_049505712.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50807.51 Da        Isoelectric Point: 9.6796

>NTDB_id=812201 P8P68_RS01485 WP_000482350.1 309562..310899(+) (ciaH) [Streptococcus sp. D7B5]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSFSASSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPDIAEVSPQFFKTTFANYELIASENDRVFNYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLTVTDNGIGISAVDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=812201 P8P68_RS01485 WP_000482350.1 309562..310899(+) (ciaH) [Streptococcus sp. D7B5]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGTTATTTTATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCAGCGATGACCTTGATTATCCTCCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTCCAAGCTC
TTAGTAGTAGTCCCCAAGCGGTTATCCAGTTAGCCCTGAATCGGGCAACTGAGGAAGTCAAGGATATTCAACCAGCAACT
GCGGATGCCAGCAAGGCTGAAATCAAACCCAATGTCAGCTCCAATACGGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGCAATCGCTTTTTAGGATTGGATAAGATCAAGCTGGACAAGAAAGAGTTGAATCATATTCGCCAAATCC
AAGTTGTCAATAGCTACGGTCAGGAAGAAACCTATCGGATGATCTTGATGGAAACTAACTCTTTCTCCGCATCAAGCAAT
GTCAAATATGCGGCGGTTTTAATCAATACCAGCCAGCTTGAACAAATCAGCCAAAACCACGAGCATTTAATTGTTGTAGT
AATGGCTAGTTTCTGGCTCCTGTCTTTAATCGCCAGTGTTTACCTAGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCTTTTGTTGAAAATGCCAGTCACGAACTGAGAACACCTTTGGCCGTTTTACAAAATCGTTTAGAG
AATCTCTTTCGAAAACCAGAGGCAACAATCATGGAATCCAGCGAAAGTATCGCTTCCAGTCTTGAAGAGGTTCGCAACAT
GCGTTTCCTCACGACCAATCTTCTCAACCTTGCACGTCGAGATGATGGAATCAAACCAGATATAGCAGAAGTTTCTCCAC
AATTCTTTAAAACAACCTTTGCCAACTATGAGTTAATTGCTTCTGAAAATGATCGTGTTTTCAACTATGAAAATCGGATT
TATCGTCCCTTTATGACCGATCAGTTGCTCTTAAAACAACTCATGACCATCTTATTTGACAATGCCATCAAGTATACCGA
AGAAGATGGGAAAATTGAGTTTGTAGTCCATGCTACAGATCGTCACCTTTATCTAACAGTAACGGATAACGGAATTGGAA
TCTCAGCTGTTGACAAGAAGAAAATCTTTGACCGATTTTACCGTGTAGACAAGGCGAGAACCCGTCAGAAAGGTGGCTTT
GGTCTTGGACTATCTTTAGCCAAGCAGATTGTTGATGCTTTGCGAGGAACGATTAGCGTGAAAGATAACAAACCTAGAGG
AACAATTTTTGAAGTTAAAATCGCTATTCAATCTCCTTCAAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB K0ZJY4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae D39

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae R6

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae TIGR4

83.747

99.551

0.834
  ciaH Streptococcus mutans UA159

54.795

98.427

0.539