Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   Q7621_RS03545 Genome accession   NZ_CP131712
Coordinates   727437..728111 (+) Length   224 a.a.
NCBI ID   WP_000590619.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 2008C09-280     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 722437..733111
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7621_RS03530 (Q7621_03525) - 722796..723236 (+) 441 WP_000612881.1 ASCH domain-containing protein -
  Q7621_RS03535 (Q7621_03530) - 723359..725905 (+) 2547 WP_341966683.1 M1 family metallopeptidase -
  Q7621_RS03540 (Q7621_03535) - 725963..727219 (-) 1257 WP_000436237.1 ISL3-like element IS1167A family transposase -
  Q7621_RS03545 (Q7621_03540) ciaR 727437..728111 (+) 675 WP_000590619.1 two-component system response regulator CiaR Regulator
  Q7621_RS03550 (Q7621_03545) ciaH 728101..729435 (+) 1335 WP_000491790.1 two-component system sensor histidine kinase CiaH Regulator
  Q7621_RS03555 (Q7621_03550) - 729469..729756 (-) 288 WP_001145225.1 DUF3270 domain-containing protein -
  Q7621_RS03560 (Q7621_03555) - 729896..730825 (+) 930 WP_000411854.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25480.32 Da        Isoelectric Point: 4.3283

>NTDB_id=791629 Q7621_RS03545 WP_000590619.1 727437..728111(+) (ciaR) [Streptococcus pneumoniae strain 2008C09-280]
MIKILLIEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=791629 Q7621_RS03545 WP_000590619.1 727437..728111(+) (ciaR) [Streptococcus pneumoniae strain 2008C09-280]
ATGATAAAAATCTTATTGATTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
TATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGATTTTGCTGGATTTGATGT
TGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTTAAAATGCGAATTCAGGCCCTTCTCAAACGTTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGG
TTAATTTATCAACCAATACCGTTAAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTAT
TTCCTTCAAAATCAAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGAT
TTCGGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.168

100

0.375
  vicR Streptococcus mutans UA159

35.193

100

0.366