Detailed information NTG0791630

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: Q7621_RS03550
• Genome accession: NZ_CP131712
• Coordinates: 728101..729435 (+)
• Length: 444 a.a.
• NCBI ID: WP_000491790.1
• Uniprot ID: Q7B3G0
• Organism: Streptococcus pneumoniae strain 2008C09-280
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 723101..734435

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7621_RS03535 (Q7621_03530)	-	723359..725905 (+)	2547	WP_341966683.1	M1 family metallopeptidase	-
Q7621_RS03540 (Q7621_03535)	-	725963..727219 (-)	1257	WP_000436237.1	ISL3-like element IS1167A family transposase	-
Q7621_RS03545 (Q7621_03540)	ciaR	727437..728111 (+)	675	WP_000590619.1	two-component system response regulator CiaR	Regulator
Q7621_RS03550 (Q7621_03545)	ciaH	728101..729435 (+)	1335	WP_000491790.1	two-component system sensor histidine kinase CiaH	Regulator
Q7621_RS03555 (Q7621_03550)	-	729469..729756 (-)	288	WP_001145225.1	DUF3270 domain-containing protein	-
Q7621_RS03560 (Q7621_03555)	-	729896..730825 (+)	930	WP_000411854.1	peptidase U32 family protein	-
Q7621_RS03565 (Q7621_03560)	-	731025..733475 (+)	2451	WP_000848695.1	bifunctional DnaQ family exonuclease/ATP-dependent helicase	-

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50673.39 Da
• Isoelectric Point: 9.1661

>NTDB_id=791630 Q7621_RS03550 WP_000491790.1 728101..729435(+) (ciaH) [Streptococcus pneumoniae strain 2008C09-280]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=791630 Q7621_RS03550 WP_000491790.1 728101..729435(+) (ciaH) [Streptococcus pneumoniae strain 2008C09-280]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAAGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAAGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTCTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterProScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

3D structure

• AlphaFold DB: Q7B3G0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	100	100	1
ciaH	Streptococcus pneumoniae D39	100	100	1
ciaH	Streptococcus pneumoniae R6	100	100	1
ciaH	Streptococcus pneumoniae TIGR4	100	100	1
ciaH	Streptococcus mutans UA159	55.632	97.973	0.545