Detailed information NTG0789632

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: PUW71_RS10065
• Genome accession: NZ_CP118053
• Coordinates: 1954598..1955788 (+)
• Length: 396 a.a.
• NCBI ID: WP_024052475.1
• Uniprot ID: -
• Organism: Streptococcus anginosus strain VSI40
• Function: repress competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1951970..1958083	1954598..1955788	within	0

Gene organization within MGE regions

Location: 1951970..1958083

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
PUW71_RS10045 (PUW71_10045)	-	1951970..1953145 (-)	1176	WP_070811584.1	IS256-like element ISSag11 family transposase	-
PUW71_RS10050 (PUW71_10050)	-	1953497..1953643 (-)	147	WP_003029519.1	bacteriocin	-
PUW71_RS10060 (PUW71_10060)	rlmH	1953925..1954404 (-)	480	WP_024052476.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
PUW71_RS10065 (PUW71_10065)	htrA	1954598..1955788 (+)	1191	WP_024052475.1	trypsin-like peptidase domain-containing protein	Regulator
PUW71_RS10070 (PUW71_10070)	spo0J	1955843..1956610 (+)	768	WP_070672281.1	ParB/RepB/Spo0J family partition protein	Regulator
PUW71_RS10075 (PUW71_10075)	-	1956908..1958083 (+)	1176	WP_070811584.1	IS256-like element ISSag11 family transposase	-

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41711.71 Da
• Isoelectric Point: 9.4264

>NTDB_id=789632 PUW71_RS10065 WP_024052475.1 1954598..1955788(+) (htrA) [Streptococcus anginosus strain VSI40]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEIFSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide

• Length: 1191 bp

>NTDB_id=789632 PUW71_RS10065 WP_024052475.1 1954598..1955788(+) (htrA) [Streptococcus anginosus strain VSI40]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATCGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTGAAAGATGCTGTGGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGCGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGGGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGAATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGTAAATTGACGGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCGCTCGGATCAAATTACGCTAACACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTTTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATTAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTTTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	75.312	100	0.763
htrA	Streptococcus mitis NCTC 12261	72.544	100	0.727
htrA	Streptococcus pneumoniae Rx1	72.292	100	0.725
htrA	Streptococcus pneumoniae D39	72.292	100	0.725
htrA	Streptococcus pneumoniae R6	72.292	100	0.725
htrA	Streptococcus pneumoniae TIGR4	72.292	100	0.725
htrA	Streptococcus mutans UA159	55.471	99.242	0.551