Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   PO908_RS05860 Genome accession   NZ_CP117042
Coordinates   1117710..1118384 (-) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus anginosus strain CGMH_KH1     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1112710..1123384
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PO908_RS05845 (PO908_05825) - 1114449..1115897 (+) 1449 WP_021001736.1 alpha-amylase -
  PO908_RS05850 (PO908_05830) - 1116094..1116228 (-) 135 WP_256381214.1 hypothetical protein -
  PO908_RS05855 (PO908_05835) ciaH 1116374..1117720 (-) 1347 WP_021001737.1 cell wall metabolism sensor histidine kinase WalK Regulator
  PO908_RS05860 (PO908_05840) ciaR 1117710..1118384 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  PO908_RS05865 (PO908_05845) - 1118657..1119109 (-) 453 WP_021001738.1 hypothetical protein -
  PO908_RS05870 (PO908_05850) - 1119434..1120177 (-) 744 WP_003024349.1 alpha/beta fold hydrolase -
  PO908_RS05880 (PO908_05860) rplS 1120419..1120766 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  PO908_RS05885 (PO908_05865) - 1120918..1121877 (-) 960 WP_021001748.1 ROK family glucokinase -
  PO908_RS05890 (PO908_05870) - 1122097..1122261 (+) 165 WP_235044308.1 LysR family transcriptional regulator -
  PO908_RS05895 (PO908_05875) - 1122242..1122841 (+) 600 WP_235044309.1 LysR family transcriptional regulator substrate-binding protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=782258 PO908_RS05860 WP_003024352.1 1117710..1118384(-) (ciaR) [Streptococcus anginosus strain CGMH_KH1]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=782258 PO908_RS05860 WP_003024352.1 1117710..1118384(-) (ciaR) [Streptococcus anginosus strain CGMH_KH1]
ATGATTAAGATTCTATTAGTGGAAGACGACCTCGGTCTATCTAATTCGGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGACGGTGAGGAAGGATTGTACGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGATTTGATGT
TGCCAGAAAAAGACGGTTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGCGTTACCACACCTGTTTTGATTATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGAGCTGACGATTATTTGACCAAACCATTTTATCTGGAAGA
ATTAAAAATGCGGATTCAAGCTCTCTTGAAGCGTTCTGGCAAGTTCAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACAAACACTACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GTAGTGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362