Detailed information NTG0761473

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: OTB22_RS05110
• Genome accession: NZ_CP113267
• Coordinates: 1013522..1014226 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain BC2
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1008522..1019226

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OTB22_RS05080 (OTB22_05085)	-	1008715..1009701 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
OTB22_RS05085 (OTB22_05090)	-	1009957..1010733 (-)	777	WP_001865265.1	potassium channel family protein	-
OTB22_RS05090 (OTB22_05095)	-	1010780..1011034 (-)	255	WP_001823540.1	type II toxin-antitoxin system RelE family toxin	-
OTB22_RS05095 (OTB22_05100)	relB	1011036..1011278 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
OTB22_RS05100 (OTB22_05105)	vicX	1011369..1012178 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
OTB22_RS05105 (OTB22_05110)	micB	1012180..1013529 (-)	1350	WP_050251702.1	cell wall metabolism sensor histidine kinase VicK	Regulator
OTB22_RS05110 (OTB22_05115)	micA	1013522..1014226 (-)	705	WP_000722076.1	response regulator YycF	Regulator
OTB22_RS05115 (OTB22_05120)	mutY	1014281..1015456 (-)	1176	WP_000886145.1	A/G-specific adenine glycosylase	-
OTB22_RS05120 (OTB22_05125)	-	1015553..1015678 (+)	126	WP_001818232.1	hypothetical protein	-
OTB22_RS05125 (OTB22_05130)	-	1015784..1017454 (-)	1671	WP_000845290.1	formate--tetrahydrofolate ligase	-
OTB22_RS05130 (OTB22_05135)	coaB	1017684..1018373 (+)	690	WP_000699495.1	phosphopantothenate--cysteine ligase	-
OTB22_RS05135 (OTB22_05140)	coaC	1018385..1018936 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=761473 OTB22_RS05110 WP_000722076.1 1013522..1014226(-) (micA) [Streptococcus pneumoniae strain BC2]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=761473 OTB22_RS05110 WP_000722076.1 1013522..1014226(-) (micA) [Streptococcus pneumoniae strain BC2]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38