Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   OTB22_RS05105 Genome accession   NZ_CP113267
Coordinates   1012180..1013529 (-) Length   449 a.a.
NCBI ID   WP_050251702.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain BC2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1007180..1018529
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OTB22_RS05080 (OTB22_05085) - 1008715..1009701 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  OTB22_RS05085 (OTB22_05090) - 1009957..1010733 (-) 777 WP_001865265.1 potassium channel family protein -
  OTB22_RS05090 (OTB22_05095) - 1010780..1011034 (-) 255 WP_001823540.1 type II toxin-antitoxin system RelE family toxin -
  OTB22_RS05095 (OTB22_05100) relB 1011036..1011278 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  OTB22_RS05100 (OTB22_05105) vicX 1011369..1012178 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  OTB22_RS05105 (OTB22_05110) micB 1012180..1013529 (-) 1350 WP_050251702.1 cell wall metabolism sensor histidine kinase VicK Regulator
  OTB22_RS05110 (OTB22_05115) micA 1013522..1014226 (-) 705 WP_000722076.1 response regulator YycF Regulator
  OTB22_RS05115 (OTB22_05120) mutY 1014281..1015456 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  OTB22_RS05120 (OTB22_05125) - 1015553..1015678 (+) 126 WP_001818232.1 hypothetical protein -
  OTB22_RS05125 (OTB22_05130) - 1015784..1017454 (-) 1671 WP_000845290.1 formate--tetrahydrofolate ligase -
  OTB22_RS05130 (OTB22_05135) coaB 1017684..1018373 (+) 690 WP_000699495.1 phosphopantothenate--cysteine ligase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51711.47 Da        Isoelectric Point: 5.1124

>NTDB_id=761472 OTB22_RS05105 WP_050251702.1 1012180..1013529(-) (micB) [Streptococcus pneumoniae strain BC2]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKKIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=761472 OTB22_RS05105 WP_050251702.1 1012180..1013529(-) (micB) [Streptococcus pneumoniae strain BC2]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTTCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAAAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

PAS fold (PAS)

(98-198)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.555

100

0.996
  vicK Streptococcus mutans UA159

69.652

89.532

0.624