Detailed information NTG0760463

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: OTU47_RS12060
• Genome accession: NZ_CP113115
• Coordinates: 2192887..2193474 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain NP2
• Function: transport of ComC (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	2189347..2195086	2192887..2193474	within	0

Gene organization within MGE regions

Location: 2189347..2195086

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OTU47_RS11465 (OTU47_11465)	-	2189347..2190152 (-)	806	Protein_2227	IS5 family transposase	-
OTU47_RS11470 (OTU47_11470)	-	2190355..2190759 (-)	405	WP_000846944.1	hypothetical protein	-
OTU47_RS11475 (OTU47_11475)	-	2190756..2190920 (-)	165	WP_000727118.1	hypothetical protein	-
OTU47_RS11480 (OTU47_11480)	-	2191219..2191338 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
OTU47_RS11485 (OTU47_11485)	blpU	2191341..2191571 (-)	231	WP_000379967.1	bacteriocin-like peptide BlpU	-
OTU47_RS11490 (OTU47_11490)	blpJ	2191640..2191909 (-)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
OTU47_RS11495 (OTU47_11495)	blpI	2192376..2192573 (-)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
OTU47_RS12060	comA/nlmT	2192887..2193474 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
OTU47_RS12065	comA/nlmT	2193419..2193880 (+)	462	WP_309543754.1	ABC transporter transmembrane domain-containing protein	Regulator
OTU47_RS11505 (OTU47_11505)	-	2194133..2195086 (+)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=760463 OTU47_RS12060 WP_000205166.1 2192887..2193474(+) (comA/nlmT) [Streptococcus pneumoniae strain NP2]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=760463 OTU47_RS12060 WP_000205166.1 2192887..2193474(+) (comA/nlmT) [Streptococcus pneumoniae strain NP2]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATCGGTGGTT
CTTATTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497