Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   UKS_RS03910 Genome accession   NZ_AP021887
Coordinates   756435..757109 (+) Length   224 a.a.
NCBI ID   WP_000590639.1    Uniprot ID   A0A419RXM2
Organism   Streptococcus sp. 116-D4     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 751435..762109
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  UKS_RS03890 (UKS_07190) - 751502..752230 (+) 729 WP_049495230.1 GNAT family N-acetyltransferase -
  UKS_RS03895 (UKS_07200) - 752269..753153 (+) 885 WP_173020456.1 putative PEP-binding protein -
  UKS_RS03900 (UKS_07210) - 753113..753553 (+) 441 WP_156011882.1 ASCH domain-containing protein -
  UKS_RS03905 (UKS_07220) - 753675..756221 (+) 2547 WP_156011883.1 M1 family metallopeptidase -
  UKS_RS03910 (UKS_07230) ciaR 756435..757109 (+) 675 WP_000590639.1 two-component system response regulator CiaR Regulator
  UKS_RS03915 (UKS_07240) ciaH 757099..758433 (+) 1335 WP_156011884.1 two-component system sensor histidine kinase CiaH Regulator
  UKS_RS03920 (UKS_07250) - 758467..758754 (-) 288 WP_156011885.1 DUF3270 domain-containing protein -
  UKS_RS03925 (UKS_07260) - 759112..760167 (+) 1056 WP_156011886.1 ABC transporter permease -
  UKS_RS03930 (UKS_07270) - 760181..760861 (+) 681 WP_156011887.1 ABC transporter ATP-binding protein -
  UKS_RS03935 (UKS_07280) - 761101..762030 (+) 930 WP_156011888.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25466.29 Da        Isoelectric Point: 4.3283

>NTDB_id=75349 UKS_RS03910 WP_000590639.1 756435..757109(+) (ciaR) [Streptococcus sp. 116-D4]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=75349 UKS_RS03910 WP_000590639.1 756435..757109(+) (ciaR) [Streptococcus sp. 116-D4]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGCCTGTCAAATTCGGTATTTGACTTTTTAGACGATTTTGCGGATGT
CATGCAGGTATTTGATGGGGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTTTGCTTGATTTGATGT
TGCCTGAAAAAAATGGCTTCCAAGTATTGAAAGAATTGCGTGAAAAGGGGATTACGACTCCAGTTCTGATCATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCGGATGATTATCTGACCAAACCTTTCTACTTAGAGGA
ACTCAAAATGAGGATTCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAATGAAAACACCTTGACTTATGGAAATATTGTAG
TTAATCTATCTACAAATACAGTAAAAGTCGAAGATACTCCTGTCGAATTGCTGGGTAAAGAGTTTGATTTATTAGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCGAAGACTCAGATTTTTGATCGTCTATGGGGATTTGATAGTGACACAACGAT
TTCAGTTGTCGAAGTTTATGTTTCAAAAGTCCGTAAGAAACTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A419RXM2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.554

100

0.996
  ciaR Streptococcus pneumoniae D39

99.554

100

0.996
  ciaR Streptococcus pneumoniae R6

99.554

100

0.996
  ciaR Streptococcus pneumoniae TIGR4

99.554

100

0.996
  ciaR Streptococcus mutans UA159

88.839

100

0.888
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment