Detailed information NTG0751092

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: OHM48_RS05260
• Genome accession: NZ_CP109942
• Coordinates: 1065768..1066439 (-)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis strain ID35541
• Function: repress competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1060400..1068600	1065768..1066439	within	0

Gene organization within MGE regions

Location: 1060400..1068600

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OHM48_RS05240 (OHM48_05240)	tnpA	1060400..1060864 (-)	465	WP_012775157.1	IS200/IS605-like element ISSsu4 family transposase	-
OHM48_RS05245 (OHM48_05245)	-	1061153..1062482 (-)	1330	Protein_989	IS1182 family transposase	-
OHM48_RS05250 (OHM48_05250)	-	1062836..1064065 (-)	1230	WP_012027071.1	transglutaminase domain-containing protein	-
OHM48_RS05255 (OHM48_05255)	ciaH	1064396..1065775 (-)	1380	WP_012775588.1	cell wall metabolism sensor histidine kinase WalK	Regulator
OHM48_RS05260 (OHM48_05260)	ciaR	1065768..1066439 (-)	672	WP_009909965.1	response regulator transcription factor	Regulator
OHM48_RS05265 (OHM48_05265)	-	1066633..1067013 (-)	381	WP_012027076.1	hypothetical protein	-
OHM48_RS05270 (OHM48_05270)	-	1067398..1068600 (+)	1203	WP_319799235.1	IS110 family transposase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=751092 OHM48_RS05260 WP_009909965.1 1065768..1066439(-) (ciaR) [Streptococcus suis strain ID35541]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=751092 OHM48_RS05260 WP_009909965.1 1065768..1066439(-) (ciaR) [Streptococcus suis strain ID35541]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TACCTGAAAAAGACGGCTTTCAAGTCTTGAAAGAGTTACGTGAAAAGGGGGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGTTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAGGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACTTTTGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363