Detailed information NTG0750879

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: OHM52_RS06040
• Genome accession: NZ_CP109937
• Coordinates: 1205967..1206638 (-)
• Length: 223 a.a.
• NCBI ID: WP_024385291.1
• Uniprot ID: A0A116K182
• Organism: Streptococcus suis strain TRG6
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1200967..1211638

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OHM52_RS06020 (OHM52_06020)	coaA	1201553..1202473 (+)	921	WP_024381359.1	type I pantothenate kinase	-
OHM52_RS06025 (OHM52_06025)	rpsT	1202532..1202780 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
OHM52_RS06030 (OHM52_06030)	-	1203042..1204271 (-)	1230	WP_024394628.1	transglutaminase domain-containing protein	-
OHM52_RS06035 (OHM52_06035)	ciaH	1204595..1205974 (-)	1380	WP_024394629.1	cell wall metabolism sensor histidine kinase WalK	Regulator
OHM52_RS06040 (OHM52_06040)	ciaR	1205967..1206638 (-)	672	WP_024385291.1	response regulator transcription factor	Regulator
OHM52_RS11515	-	1206832..1207167 (-)	336	Protein_1161	hypothetical protein	-
OHM52_RS06050 (OHM52_06050)	phoU	1207333..1207989 (-)	657	WP_024394630.1	phosphate signaling complex protein PhoU	-
OHM52_RS06055 (OHM52_06055)	pstB	1208018..1208776 (-)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
OHM52_RS06060 (OHM52_06060)	pstB	1208788..1209591 (-)	804	WP_002937615.1	phosphate ABC transporter ATP-binding protein PstB	-
OHM52_RS06065 (OHM52_06065)	pstA	1209616..1210503 (-)	888	WP_002937616.1	phosphate ABC transporter permease PstA	-
OHM52_RS06070 (OHM52_06070)	pstC	1210493..1211410 (-)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25231.80 Da
• Isoelectric Point: 4.2183

>NTDB_id=750879 OHM52_RS06040 WP_024385291.1 1205967..1206638(-) (ciaR) [Streptococcus suis strain TRG6]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=750879 OHM52_RS06040 WP_024385291.1 1205967..1206638(-) (ciaR) [Streptococcus suis strain TRG6]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACGAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A116K182

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368