Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   OF800_RS09315 Genome accession   NZ_CP109636
Coordinates   1858860..1860077 (+) Length   405 a.a.
NCBI ID   WP_003133516.1    Uniprot ID   A0A3D4RHV6
Organism   Lactococcus garvieae strain Alexii-6_2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1853860..1865077
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  OF800_RS09285 (OF800_09285) eeP 1853871..1855118 (-) 1248 WP_014025467.1 RIP metalloprotease RseP Regulator
  OF800_RS09290 (OF800_09290) - 1855294..1856088 (-) 795 WP_003133509.1 phosphatidate cytidylyltransferase -
  OF800_RS09295 (OF800_09295) - 1856085..1856822 (-) 738 WP_003133511.1 isoprenyl transferase -
  OF800_RS09300 (OF800_09300) yajC 1857023..1857358 (-) 336 WP_264308065.1 preprotein translocase subunit YajC -
  OF800_RS09305 (OF800_09305) - 1857433..1858080 (-) 648 WP_264308066.1 DNA alkylation repair protein -
  OF800_RS09310 (OF800_09310) rlmH 1858077..1858556 (-) 480 WP_264308067.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  OF800_RS09315 (OF800_09315) htrA 1858860..1860077 (+) 1218 WP_003133516.1 trypsin-like peptidase domain-containing protein Regulator
  OF800_RS09320 (OF800_09320) - 1860175..1861173 (+) 999 WP_264308069.1 glycosyltransferase family 4 protein -
  OF800_RS09325 (OF800_09325) - 1861186..1862520 (+) 1335 WP_003133518.1 glycosyltransferase family 4 protein -
  OF800_RS09330 (OF800_09330) - 1862571..1862795 (+) 225 WP_003133519.1 DUF1797 family protein -
  OF800_RS09335 (OF800_09335) - 1862821..1863870 (-) 1050 WP_003133520.1 BMP family protein -
  OF800_RS09340 (OF800_09340) - 1864029..1864778 (-) 750 WP_019298937.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -

Sequence

Protein


Download         Length: 405 a.a.        Molecular weight: 41787.63 Da        Isoelectric Point: 4.8808

>NTDB_id=748707 OF800_RS09315 WP_003133516.1 1858860..1860077(+) (htrA) [Lactococcus garvieae strain Alexii-6_2]
MAKKNIASLLITGVAGGAIALGGSAIYQNMTNTPSSNNTSDNSVSTVNVQVNTDTTKAIKKISNTVVSVLNYQKSSSSND
FEKIFGGGDTSSNDSNTPQLAGEGSGVIYKKDGNTAYIVTNYHVIEGASSLEVLMAGGQKVTAEVVGSDAYSDLAVLKID
AKYVKETATFGNSDKLTVGEPAIAVGSPLGSEYANSATEGIVSSLNRNVTLQNSQGQTINVNAIQTDAAINPGNSGGALI
NIQGQVIGITSSKITSTPSGTSGSGVSVEGMGFAIPANDVVNIINKLEKDGKVIRPALGVQMVNLSSLSQNMLASLNLPE
NVTNGVAIAEVQSGMPAAKAGLKQGDVIVKINDDEITSSVNLQSTLYKSSIGDTIKVTYYRDGKQATANIKLDKTSSDIN
FDKQN

Nucleotide


Download         Length: 1218 bp        

>NTDB_id=748707 OF800_RS09315 WP_003133516.1 1858860..1860077(+) (htrA) [Lactococcus garvieae strain Alexii-6_2]
ATGGCAAAGAAAAATATCGCCTCATTACTTATTACGGGCGTAGCCGGAGGTGCTATCGCTCTTGGAGGTAGTGCTATCTA
CCAAAACATGACCAATACACCATCATCTAATAACACTTCGGACAATTCTGTAAGTACGGTTAACGTCCAAGTCAATACAG
ATACCACCAAAGCAATCAAGAAAATTTCGAACACTGTTGTTTCCGTTCTTAATTACCAAAAATCATCCTCAAGCAACGAT
TTTGAGAAGATTTTCGGTGGAGGCGATACAAGCAGCAATGACAGTAACACGCCACAGCTGGCTGGTGAAGGTTCTGGTGT
TATTTATAAAAAGGATGGCAATACAGCATACATCGTCACCAACTATCACGTGATTGAAGGTGCTTCTTCCTTAGAAGTTC
TCATGGCTGGCGGCCAAAAAGTTACTGCTGAAGTTGTTGGTTCTGATGCTTATTCTGATTTAGCTGTCCTCAAAATTGAT
GCTAAGTATGTCAAAGAAACAGCAACATTCGGTAACTCTGACAAACTTACTGTTGGTGAGCCCGCTATCGCGGTTGGTTC
TCCTCTTGGAAGTGAGTATGCCAACTCAGCAACGGAAGGGATTGTTTCAAGTCTTAATCGTAATGTTACGCTGCAAAACA
GCCAAGGCCAAACAATTAATGTGAACGCAATTCAAACCGATGCAGCAATTAACCCAGGTAACTCTGGTGGTGCACTCATA
AATATTCAGGGACAAGTCATCGGGATTACTTCAAGTAAAATTACCTCAACACCAAGCGGAACAAGCGGCAGTGGTGTTTC
TGTAGAAGGAATGGGCTTTGCGATACCAGCCAATGATGTGGTCAATATTATCAATAAGTTGGAAAAAGATGGCAAAGTTA
TTCGACCTGCTCTCGGTGTACAAATGGTCAACTTGTCAAGTCTTTCACAAAATATGTTGGCTTCACTTAATCTTCCTGAA
AATGTGACAAATGGTGTTGCTATCGCTGAAGTTCAATCAGGAATGCCTGCTGCCAAAGCTGGACTCAAGCAAGGTGACGT
TATTGTCAAAATCAATGATGACGAAATCACTTCAAGTGTGAACCTTCAAAGTACACTTTATAAGTCATCGATTGGTGATA
CGATTAAGGTAACTTATTATCGTGACGGAAAACAAGCTACTGCGAATATCAAGTTGGATAAGACAAGTAGTGACATCAAC
TTTGACAAACAAAATTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(296-392)

Peptidase family M50 (Peptidase_M50)

(294-396)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3D4RHV6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

53.634

98.519

0.528
  htrA Streptococcus pneumoniae Rx1

53.383

98.519

0.526
  htrA Streptococcus pneumoniae D39

53.383

98.519

0.526
  htrA Streptococcus pneumoniae R6

53.383

98.519

0.526
  htrA Streptococcus pneumoniae TIGR4

53.383

98.519

0.526
  htrA Streptococcus mutans UA159

56.085

93.333

0.523
  htrA Streptococcus gordonii str. Challis substr. CH1

54.22

96.543

0.523