NTDB

Overview

Name	micA	Type	Regulator
Locus tag	ODS73_RS06425	Genome accession	NZ_CP107038
Coordinates	1254766..1255470 (-)	Length	234 a.a.
NCBI ID	WP_000722076.1	Uniprot ID	Q9S1K0
Organism	Streptococcus pneumoniae strain BM6001
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1249766..1260470

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ODS73_RS06395 (ODS73_06390)	-	1249955..1250941 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
ODS73_RS06400 (ODS73_06395)	-	1251204..1251977 (-)	774	WP_044811410.1	potassium channel family protein	-
ODS73_RS06405 (ODS73_06400)	-	1252024..1252278 (-)	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ODS73_RS06410 (ODS73_06405)	relB	1252280..1252522 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
ODS73_RS06415 (ODS73_06410)	vicX	1252613..1253422 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
ODS73_RS06420 (ODS73_06415)	micB	1253424..1254773 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ODS73_RS06425 (ODS73_06420)	micA	1254766..1255470 (-)	705	WP_000722076.1	response regulator YycF	Regulator
ODS73_RS06430 (ODS73_06425)	mutY	1255525..1256700 (-)	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
ODS73_RS06435 (ODS73_06430)	-	1257028..1258698 (-)	1671	WP_050212016.1	formate--tetrahydrofolate ligase	-
ODS73_RS06440 (ODS73_06435)	coaB	1258928..1259617 (+)	690	WP_050212017.1	phosphopantothenate--cysteine ligase	-
ODS73_RS06445 (ODS73_06440)	coaC	1259629..1260180 (+)	552	WP_001284129.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

Download Length: 234 a.a. Molecular weight: 26815.63 Da Isoelectric Point: 4.7164

                                >NTDB_id=737551 ODS73_RS06425 WP_000722076.1 1254766..1255470(-) (micA) [Streptococcus pneumoniae strain BM6001]

MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA

KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT

HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

Download Length: 705 bp

                                >NTDB_id=737551 ODS73_RS06425 WP_000722076.1 1254766..1255470(-) (micA) [Streptococcus pneumoniae strain BM6001]

ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA

AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA

TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC

AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA

GTTGCAGGCACGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC

AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC

CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT

CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC

CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
PDB	1NXS
PDB	2A9O
PDB	2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38

Detailed information NTG0737551