Detailed information    

insolico Bioinformatically predicted

Overview

Name   stkP   Type   Regulator
Locus tag   PUW49_RS02240 Genome accession   NZ_CP118054
Coordinates   441048..442922 (+) Length   624 a.a.
NCBI ID   WP_024052108.1    Uniprot ID   A0A6G4MWZ5
Organism   Streptococcus anginosus strain VSI37     
Function   require for competence development; phosphorylate ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 436048..447922
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  PUW49_RS02225 (PUW49_02225) fmt 438054..438989 (+) 936 WP_024052110.1 methionyl-tRNA formyltransferase -
  PUW49_RS02230 (PUW49_02230) rsmB 438979..440292 (+) 1314 WP_070583972.1 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB -
  PUW49_RS02235 (PUW49_02235) - 440311..441051 (+) 741 WP_022526377.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  PUW49_RS02240 (PUW49_02240) stkP 441048..442922 (+) 1875 WP_024052108.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  PUW49_RS02245 (PUW49_02245) liaF 443183..443881 (+) 699 WP_024052107.1 cell wall-active antibiotics response protein LiaF -
  PUW49_RS02250 (PUW49_02250) - 443878..444873 (+) 996 WP_024052106.1 sensor histidine kinase -
  PUW49_RS02255 (PUW49_02255) vraR 444875..445501 (+) 627 WP_274994886.1 response regulator transcription factor Regulator
  PUW49_RS02260 (PUW49_02260) - 445548..446948 (+) 1401 WP_070241554.1 Cof-type HAD-IIB family hydrolase -
  PUW49_RS02265 (PUW49_02265) - 446950..447321 (+) 372 WP_024052103.1 S1 RNA-binding domain-containing protein -
  PUW49_RS02270 (PUW49_02270) - 447455..447772 (-) 318 WP_024052102.1 DUF960 domain-containing protein -

Sequence

Protein


Download         Length: 624 a.a.        Molecular weight: 67729.81 Da        Isoelectric Point: 9.4166

>NTDB_id=720867 PUW49_RS02240 WP_024052108.1 441048..442922(+) (stkP) [Streptococcus anginosus strain VSI37]
MIQVGKIFAGRYRIIKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEEGQQYLAMEYVAGLDLKRYIKEHAPLSNEEAVRIMGQILLAMRLAHTHGIVHRDLKPQNVLLTPDGDAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSIIAENPNVP
QALENVVIKATAKKLTDRYQSVAEMYVDLSSCLSADRRNEKKLVFDDTAKADTKTLPKVSQNTLTSATKPTPAPTKEAVS
SKPTPKPKAKKKRRLRTRYKVLLSAVVLVIAALVALVYLSPSNVKIPDVTGKTIAQARSAIETAGLKVGKEKDEYSDSVK
KDSVIRTNPEAGTQRREGSTVDLIVSKGTKTFIMEDYKGQKRADAINNLVQKYKVSKGLIKTEEVESSEYAAGTVVDQTP
AAGSTYDLTSKTRITLKVAKSVSSVTMPSYISSTYEFAYNNLTEVIGIQGANIEKRSITTAPTGTQANTIIRQTPEAGQS
LNLKSDRIVLYVYEPKTEDSSTSESSSQSDSSSDKTSPSSSSSSASGNDGSSSKTPDTSASASN

Nucleotide


Download         Length: 1875 bp        

>NTDB_id=720867 PUW49_RS02240 WP_024052108.1 441048..442922(+) (stkP) [Streptococcus anginosus strain VSI37]
ATGATTCAAGTCGGCAAGATATTTGCCGGACGATATAGAATCATCAAACAAATTGGCCGAGGAGGTATGGCAGATGTCTA
CTTGGCGAAAGACTTGATTTTAGACGGGGAAGAAGTCGCAGTTAAGGTTCTAAGAACCAATTACCAGACAGATCCGATTG
CTGTAGCACGTTTTCAAAGAGAAGCACGCGCCATGGCAGACTTGGATCATCCTCATATTGTCCGGATTACCGACATTGGA
GAAGAAGAAGGCCAGCAGTATTTAGCAATGGAATATGTGGCTGGACTTGACTTAAAACGCTATATCAAAGAGCATGCTCC
TTTGTCTAATGAAGAAGCGGTTCGTATCATGGGACAAATCCTTTTAGCGATGCGTTTGGCGCACACGCATGGGATTGTTC
ACCGTGATTTGAAACCTCAAAATGTCCTTTTAACTCCAGATGGCGATGCAAAAGTCACTGACTTTGGAATTGCGGTAGCT
TTTGCAGAAACGAGTTTAACGCAAACCAACTCTATGTTGGGGTCTGTACATTATTTGTCACCAGAACAGGCGCGTGGTTC
AAAAGCGACCGTTCAGAGTGATATTTATGCCATGGGGATTATTTTCTATGAAATGCTGACAGGACATATCCCTTATGATG
GAGATAGTGCTGTTACGATTGCCCTACAGCATTTCCAAAAGCCTCTACCGTCCATTATTGCTGAAAATCCAAACGTTCCA
CAGGCATTGGAAAATGTAGTCATCAAGGCAACGGCAAAAAAATTGACGGATCGTTATCAGTCAGTTGCAGAAATGTATGT
GGATTTATCAAGCTGTTTATCTGCTGACCGTCGAAATGAGAAAAAACTAGTTTTTGATGACACGGCTAAGGCAGACACAA
AGACACTGCCGAAAGTGTCACAAAATACTTTGACTTCTGCGACGAAGCCAACACCTGCTCCCACAAAAGAAGCAGTCAGT
AGTAAACCTACGCCTAAGCCAAAAGCAAAAAAGAAGCGCCGTTTAAGAACACGCTATAAAGTTTTGTTATCAGCAGTGGT
TTTAGTTATCGCAGCTCTGGTGGCTTTGGTCTATTTGAGTCCATCAAATGTAAAAATTCCAGATGTTACTGGAAAAACTA
TTGCCCAAGCACGTTCTGCAATCGAAACTGCAGGTTTGAAAGTTGGCAAGGAAAAAGACGAATACAGTGATTCTGTTAAA
AAAGATTCAGTCATTCGCACCAATCCAGAAGCGGGAACGCAACGTCGTGAGGGCAGTACGGTGGATCTGATTGTCTCAAA
AGGGACTAAAACTTTTATTATGGAAGATTATAAAGGTCAGAAAAGAGCAGATGCCATCAACAATCTGGTACAAAAATACA
AGGTTTCAAAAGGTTTAATTAAAACAGAAGAAGTTGAGAGTAGTGAGTATGCGGCAGGAACAGTTGTTGATCAAACACCA
GCAGCAGGCAGCACTTATGATTTGACTTCAAAGACCCGTATTACGTTAAAAGTAGCGAAGTCCGTTTCAAGTGTCACGAT
GCCAAGCTATATCAGTTCAACCTATGAATTTGCTTATAATAATTTGACGGAAGTGATTGGTATTCAAGGTGCGAATATTG
AAAAACGTTCGATTACAACAGCTCCAACGGGTACACAGGCAAATACGATTATCAGACAAACCCCAGAAGCTGGTCAGTCT
TTGAATTTGAAGAGTGATCGCATTGTCTTATATGTATATGAGCCAAAAACCGAAGATTCTTCAACATCTGAAAGTAGTTC
ACAATCTGATAGCAGCTCAGATAAAACTAGCCCATCCTCTAGCAGTTCGTCAGCTAGTGGTAATGATGGGAGCAGCTCAA
AAACACCAGACACAAGTGCTAGTGCAAGTAATTAA

Domains

Predicted by InterProScan.

Protein kinase domain (Pkinase)

(12-232)

PASTA domain (PASTA)

(364-427)

PASTA domain (PASTA)

(505-573)

PASTA domain (PASTA)

(433-500)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6G4MWZ5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  stkP Streptococcus pneumoniae TIGR4

65.874

94.391

0.622
  stkP Streptococcus pneumoniae D39

65.535

94.391

0.619
  stkP Streptococcus pneumoniae R6

65.535

94.391

0.619
  stkP Streptococcus pneumoniae Rx1

65.365

94.391

0.617
  pknB Streptococcus mutans UA159

59.316

93.75

0.556
  stkP/pknB Streptococcus salivarius strain HSISS4

55.686

95.833

0.534