Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   EL263_RS05990 Genome accession   NZ_AP018938
Coordinates   1134837..1135541 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain ATCC 49619     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1129837..1140541
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL263_RS05960 (SPAT_1125) - 1130026..1131012 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  EL263_RS05965 (SPAT_1126) - 1131275..1132048 (-) 774 WP_044811410.1 potassium channel family protein -
  EL263_RS05970 (SPAT_1127) - 1132095..1132349 (-) 255 WP_001812387.1 type II toxin-antitoxin system RelE family toxin -
  EL263_RS05975 (SPAT_1128) relB 1132351..1132593 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  EL263_RS05980 (SPAT_1129) vicX 1132684..1133493 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  EL263_RS05985 (SPAT_1130) micB 1133495..1134844 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  EL263_RS05990 (SPAT_1131) micA 1134837..1135541 (-) 705 WP_000722076.1 response regulator YycF Regulator
  EL263_RS05995 (SPAT_1132) mutY 1135596..1136771 (-) 1176 WP_000886125.1 A/G-specific adenine glycosylase -
  EL263_RS06005 (SPAT_1133) - 1137100..1138770 (-) 1671 WP_000845292.1 formate--tetrahydrofolate ligase -
  EL263_RS06010 (SPAT_1134) coaB 1139000..1139689 (+) 690 WP_000699498.1 phosphopantothenate--cysteine ligase -
  EL263_RS06015 (SPAT_1135) coaC 1139701..1140252 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=71943 EL263_RS05990 WP_000722076.1 1134837..1135541(-) (micA) [Streptococcus pneumoniae strain ATCC 49619]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=71943 EL263_RS05990 WP_000722076.1 1134837..1135541(-) (micA) [Streptococcus pneumoniae strain ATCC 49619]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment