Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   MGCS35823_RS02825 Genome accession   NZ_CP117289
Coordinates   525552..527705 (-) Length   717 a.a.
NCBI ID   WP_084916306.1    Uniprot ID   A0A223M041
Organism   Streptococcus dysgalactiae subsp. equisimilis strain MGCS35823     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 520552..532705
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGCS35823_RS02805 (MGCS35823_01140) - 521507..522640 (-) 1134 WP_275902597.1 ISAs1-like element IS1548 family transposase -
  MGCS35823_RS02810 (MGCS35823_01142) comD/blpH 523003..523827 (+) 825 WP_275910586.1 GHKL domain-containing protein Regulator
  MGCS35823_RS02815 (MGCS35823_01144) - 523975..524100 (-) 126 WP_011017462.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  MGCS35823_RS02820 (MGCS35823_01148) - 524177..525541 (-) 1365 WP_084916305.1 bacteriocin secretion accessory protein -
  MGCS35823_RS02825 (MGCS35823_01150) comA/nlmT 525552..527705 (-) 2154 WP_084916306.1 peptide cleavage/export ABC transporter Regulator
  MGCS35823_RS02830 (MGCS35823_01152) - 527992..528219 (+) 228 WP_002992018.1 Blp family class II bacteriocin -
  MGCS35823_RS02835 (MGCS35823_01154) - 528232..528432 (+) 201 WP_003060803.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  MGCS35823_RS02840 (MGCS35823_01156) - 528726..528920 (+) 195 WP_002990768.1 hypothetical protein -
  MGCS35823_RS02845 (MGCS35823_01158) - 528968..529249 (+) 282 WP_011054252.1 hypothetical protein -
  MGCS35823_RS02850 (MGCS35823_01160) - 529443..529853 (+) 411 WP_275910587.1 hypothetical protein -
  MGCS35823_RS02855 - 530100..530347 (+) 248 Protein_505 hypothetical protein -
  MGCS35823_RS02860 (MGCS35823_01162) - 530369..530623 (+) 255 WP_014612089.1 CPBP family intramembrane glutamic endopeptidase -
  MGCS35823_RS02865 (MGCS35823_01166) - 531035..531772 (+) 738 WP_228113938.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80504.46 Da        Isoelectric Point: 7.1728

>NTDB_id=717805 MGCS35823_RS02825 WP_084916306.1 525552..527705(-) (comA/nlmT) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35823]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVIYQNKKNYLIIGDPDSTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVGYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=717805 MGCS35823_RS02825 WP_084916306.1 525552..527705(-) (comA/nlmT) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS35823]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCATCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACTCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAT
GTTATTTTATCCTATATTCGTCATATTTTTGAGCTTCCCATGTCTTTCTTTGCAACACGTCGGACAGGAGAAATCATCTC
ACGTTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGGCTATCTGGATAAATCCTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGCA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterProScan.

ABC transporter transmembrane region (ABC_membrane)

(168-438)

ABC transporter (ABC_tran)

(500-649)

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A223M041

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

72.448

99.721

0.722
  comA Streptococcus mitis NCTC 12261

67.227

99.582

0.669
  comA Streptococcus mitis SK321

66.807

99.582

0.665
  comA Streptococcus pneumoniae Rx1

66.807

99.582

0.665
  comA Streptococcus pneumoniae D39

66.807

99.582

0.665
  comA Streptococcus pneumoniae R6

66.807

99.582

0.665
  comA Streptococcus pneumoniae TIGR4

66.527

99.582

0.662
  comA Streptococcus gordonii str. Challis substr. CH1

65.738

100

0.658