Detailed information NTG0717652

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: MGCS36044_RS09600
• Genome accession: NZ_CP117287
• Coordinates: 1943870..1944610 (-)
• Length: 246 a.a.
• NCBI ID: WP_003061418.1
• Uniprot ID: Q8KQN2
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain MGCS36044
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1938870..1949610

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGCS36044_RS09575 (MGCS36044_03856)	-	1939769..1940473 (-)	705	WP_003056091.1	N-acetylmannosamine-6-phosphate 2-epimerase	-
MGCS36044_RS09580 (MGCS36044_03858)	rpmH	1940803..1940937 (-)	135	WP_002885866.1	50S ribosomal protein L34	-
MGCS36044_RS09585 (MGCS36044_03860)	jag	1941250..1942164 (-)	915	WP_003056081.1	RNA-binding cell elongation regulator Jag/EloR	-
MGCS36044_RS09590 (MGCS36044_03862)	-	1942176..1943003 (-)	828	WP_100249539.1	YidC/Oxa1 family membrane protein insertase	-
MGCS36044_RS09595 (MGCS36044_03864)	rnpA	1942969..1943328 (-)	360	WP_003056083.1	ribonuclease P protein component	-
MGCS36044_RS09600 (MGCS36044_03868)	comE/blpR	1943870..1944610 (-)	741	WP_003061418.1	response regulator transcription factor	Regulator
MGCS36044_RS09605 (MGCS36044_03870)	-	1944614..1945897 (-)	1284	WP_084916681.1	sensor histidine kinase	-
MGCS36044_RS09610 (MGCS36044_03872)	-	1945898..1947241 (-)	1344	WP_015058070.1	sensor histidine kinase	-
MGCS36044_RS09615 (MGCS36044_03874)	gltX	1947856..1949304 (-)	1449	WP_014612594.1	glutamate--tRNA ligase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28977.28 Da
• Isoelectric Point: 4.8645

>NTDB_id=717652 MGCS36044_RS09600 WP_003061418.1 1943870..1944610(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS36044]
MMNIFILEDDFIQQTRIESVVADILEEAKIPCNQLEVFANPHKLFESIQERGDHQLYFLDIEIGDEDRRGLELAADIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAVDKQQFRDQIEECIRYTYEMMSSRESEDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFDNGDSCMVSRLKMKCLFE
KWEALH

Nucleotide

• Length: 741 bp

>NTDB_id=717652 MGCS36044_RS09600 WP_003061418.1 1943870..1944610(-) (comE/blpR) [Streptococcus dysgalactiae subsp. equisimilis strain MGCS36044]
ATGATGAATATTTTTATTCTTGAAGATGATTTTATCCAACAGACACGTATTGAATCTGTAGTGGCAGACATCTTGGAAGA
AGCTAAAATCCCTTGTAATCAGCTAGAAGTGTTTGCCAATCCTCATAAATTATTTGAAAGCATTCAAGAAAGAGGCGATC
ACCAGCTATATTTTTTAGACATTGAGATTGGTGATGAGGATCGCCGAGGGCTTGAATTGGCAGCAGATATTCGACAAAAA
GACCCCAATGCGGTCATTGTGTTTGTTACCACACATTCTGAATTTGCTCCTATTTCTTTTAAATACAAAGTGTCTGCCTT
AGATTTTATTGACAAAGCAGTTGATAAACAACAATTTAGGGATCAGATTGAAGAATGTATCCGCTATACCTATGAGATGA
TGTCTAGCCGAGAATCAGAAGACATGTTTTTATTTGAGACCCCTCAGACAAGGTTAAAATTACCTTACAAAGATATCCTT
TATTTTGCTACTGCTACGACACCCCACAAGGTGTGTTTGTGGACTCAGACGGAGAGACTGGAGTTTTATGGTAATTTATC
TGAGATACAAGCTGTGGCTCCAAAGCTTTTCTTATGCCATAGATCTTACTTGGTTAATCTAGATAAGGTTGTGCGTATTG
ATAAATCCAAACAGCTCCTCTATTTCGATAATGGGGATTCCTGTATGGTCTCACGCTTAAAAATGAAATGCCTTTTTGAA
AAATGGGAAGCCTTACATTAA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-123)

• LytTr DNA-binding domain (LytTR) (152-242)

3D structure

• AlphaFold DB: Q8KQN2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	47.699	97.154	0.463
comE/comE1	Streptococcus equinus JB1	42.437	96.748	0.411
comE/comE2	Streptococcus equinus JB1	40.408	99.593	0.402
comE/comE2	Streptococcus gordonii strain NCTC7865	39.113	100	0.394
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.113	100	0.394