Detailed information NTG0071752

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: EL269_RS05510
• Genome accession: NZ_AP018935
• Coordinates: 1039638..1040480 (-)
• Length: 280 a.a.
• NCBI ID: WP_001015240.1
• Uniprot ID: Q8DZU1
• Organism: Streptococcus agalactiae strain HU-GS5823
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1034638..1045480

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL269_RS05500 (SAGS_1040)	-	1036585..1037286 (-)	702	WP_000120355.1	ABC transporter ATP-binding protein	-
EL269_RS05505 (SAGS_1041)	topA	1037423..1039543 (-)	2121	WP_000246611.1	type I DNA topoisomerase	-
EL269_RS05510 (SAGS_1042)	dprA	1039638..1040480 (-)	843	WP_001015240.1	DNA-processing protein DprA	Machinery gene
EL269_RS05515 (SAGS_1043)	-	1040618..1041646 (-)	1029	WP_000162771.1	siderophore ABC transporter substrate-binding protein	-
EL269_RS05520 (SAGS_1044)	-	1041708..1042469 (-)	762	WP_000614752.1	ABC transporter ATP-binding protein	-
EL269_RS05525 (SAGS_1045)	-	1042466..1043440 (-)	975	WP_000588576.1	iron chelate uptake ABC transporter family permease subunit	-
EL269_RS05530 (SAGS_1046)	-	1043437..1044399 (-)	963	WP_000735588.1	ABC transporter permease	-
EL269_RS05535 (SAGS_1047)	-	1044638..1045186 (-)	549	WP_000136509.1	sugar O-acetyltransferase	-

Sequence

Protein

• Length: 280 a.a.
• Molecular weight: 31294.36 Da
• Isoelectric Point: 9.3802

>NTDB_id=71752 EL269_RS05510 WP_001015240.1 1039638..1040480(-) (dprA) [Streptococcus agalactiae strain HU-GS5823]
MNHFELFKLKKAGLTNLNIHNIINYLKKNSLTSLSVRNMAVVSKCKNPTFFIENYKQLDLKKLRQEFKKFPVLSILDSNY
PLELKEIYNPPVLLFYQGNIELLSKPKLAVVGARQASQIGCQSVKKIIKETNNQFVIVSGLARGIDTAAHVSALKNGGSS
IAVIGSGLDVYYPTENKKLQEYMSYNHLVLSEYFTGEQPLKFHFPERNRIIAGLCQGIVVAEAKMRSGSLITCERALEEG
REVFAIPGNIIDGKSDGCHHLIQEGAKCIISGKDILSEYQ

Nucleotide

• Length: 843 bp

>NTDB_id=71752 EL269_RS05510 WP_001015240.1 1039638..1040480(-) (dprA) [Streptococcus agalactiae strain HU-GS5823]
ATGAATCATTTTGAACTATTTAAGCTTAAAAAAGCTGGATTAACAAATCTTAATATCCACAATATTATCAACTATCTCAA
AAAGAATAGTTTAACTTCTCTATCTGTTCGCAATATGGCCGTAGTATCAAAATGTAAAAATCCTACTTTCTTTATAGAAA
ATTATAAACAGCTAGACCTTAAAAAACTTCGACAAGAATTCAAAAAATTTCCAGTTCTATCGATTTTGGATTCTAACTAT
CCTTTAGAGTTAAAAGAAATATATAATCCACCAGTTCTACTTTTTTATCAGGGTAATATTGAACTTCTATCTAAACCTAA
ATTAGCTGTAGTGGGGGCAAGACAGGCATCTCAGATAGGTTGTCAGTCTGTTAAAAAGATTATCAAGGAGACTAACAATC
AATTTGTTATCGTAAGTGGTTTAGCGCGTGGCATTGATACAGCAGCACATGTTAGTGCTTTAAAAAATGGCGGCAGTAGT
ATAGCTGTTATCGGGAGTGGTTTAGATGTTTATTATCCAACGGAGAATAAGAAACTTCAAGAATATATGTCATATAATCA
TCTCGTATTATCAGAATATTTTACCGGAGAACAACCCTTGAAATTTCATTTCCCCGAACGTAACCGTATTATTGCAGGGC
TGTGTCAAGGTATTGTGGTTGCCGAAGCTAAGATGAGATCTGGAAGTTTAATTACCTGTGAAAGAGCATTAGAAGAGGGA
CGAGAAGTTTTTGCCATTCCCGGAAATATTATCGATGGCAAATCAGATGGATGCCACCATCTTATCCAAGAAGGAGCTAA
ATGCATTATTTCAGGAAAAGATATCCTTTCTGAATATCAGTAG

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (69-270)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-63)

3D structure

• AlphaFold DB: Q8DZU1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	70.251	99.643	0.7
dprA/cilB/dalA	Streptococcus mitis SK321	62.5	100	0.625
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	61.786	100	0.618
dprA/cilB/dalA	Streptococcus pneumoniae D39	61.786	100	0.618
dprA/cilB/dalA	Streptococcus pneumoniae R6	61.786	100	0.618
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	61.786	100	0.618
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	61.429	100	0.614
dprA	Lactococcus lactis subsp. cremoris KW2	60.932	99.643	0.607
dprA	Latilactobacillus sakei subsp. sakei 23K	42.231	89.643	0.379