Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   NPS18_RS10065 Genome accession   NZ_CP101984
Coordinates   2030615..2031823 (+) Length   402 a.a.
NCBI ID   WP_002262650.1    Uniprot ID   Q8DRQ6
Organism   Streptococcus mutans strain UA-159     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2025615..2036823
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NPS18_RS10055 (NPS18_10055) - 2028925..2029587 (-) 663 WP_002262652.1 YoaK family protein -
  NPS18_RS10060 (NPS18_10060) rlmH 2029930..2030409 (-) 480 WP_002262651.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  NPS18_RS10065 (NPS18_10065) htrA 2030615..2031823 (+) 1209 WP_002262650.1 S1C family serine protease Regulator
  NPS18_RS10070 (NPS18_10070) spo0J 2032301..2033071 (+) 771 WP_002262649.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 402 a.a.        Molecular weight: 43071.55 Da        Isoelectric Point: 8.8092

>NTDB_id=713546 NPS18_RS10065 WP_002262650.1 2030615..2031823(+) (htrA) [Streptococcus mutans strain UA-159]
MNNTKSHPFLKWFIPFLVIFLTFILGVISTLTFNWITGNKSFSNNGKTTVSNVIYDTKSNTTKAVKNVKNTVVSVINYQK
TDNSYYNYDSGSQEKNKSEDGLGVYGEGSGVIYKKDGDSAYLVTNNHVVKDAEKLEIMMANGKKVVGKLVGSDTYSDLAV
IKISSKYVTTVAEFANSDKIKVGEPAIAIGSPLGSDYANSVTEGIVSSLSRTVTSQNENGETISTNAIQTDAAINPGNSG
GALINIKGQVIGINSSKIASSNNSNSGVAVEGMGFAIPSNDVVSIINQLEENGEVVRPALGISMANLSEASTSGRDTLKI
PSDVTSGIVVLSTQSGMPADGKLKKYDVITEIDGKKVASISDLQSILYKHKKGDKIKLTFYREKDKQTVEIQLTKTSQDL
NH

Nucleotide


Download         Length: 1209 bp        

>NTDB_id=713546 NPS18_RS10065 WP_002262650.1 2030615..2031823(+) (htrA) [Streptococcus mutans strain UA-159]
GTGAATAATACGAAATCTCACCCTTTTTTAAAATGGTTTATACCTTTTTTAGTTATTTTTTTAACTTTTATTTTAGGGGT
CATATCAACACTTACCTTTAATTGGATAACTGGTAACAAATCGTTTTCTAACAATGGAAAAACAACTGTTAGTAATGTCA
TTTATGATACCAAATCTAACACTACCAAGGCTGTTAAAAATGTCAAAAATACAGTTGTATCTGTCATCAATTATCAAAAA
ACAGATAATAGTTATTACAATTATGACAGCGGTTCTCAAGAAAAAAATAAATCAGAGGATGGTCTAGGAGTCTACGGTGA
AGGTTCTGGTGTTATCTATAAAAAAGATGGCGATAGTGCTTATTTAGTTACAAACAATCATGTCGTTAAAGATGCAGAAA
AGTTAGAAATCATGATGGCTAATGGTAAAAAAGTTGTCGGTAAATTAGTAGGTTCTGATACTTATTCTGATCTGGCTGTT
ATTAAAATTTCTTCTAAGTATGTTACGACAGTTGCTGAATTTGCTAATTCGGATAAAATAAAAGTTGGAGAACCAGCAAT
CGCTATTGGTAGCCCTTTAGGCAGTGATTATGCTAATTCTGTAACAGAAGGAATTGTTTCAAGTCTCAGTCGTACAGTAA
CTTCACAAAATGAAAATGGCGAAACAATTTCAACTAATGCTATTCAAACAGACGCAGCTATTAACCCTGGTAATTCTGGT
GGCGCTTTAATTAATATCAAAGGACAAGTTATTGGTATCAATTCAAGTAAAATTGCATCAAGTAATAACTCAAATAGTGG
CGTTGCTGTTGAAGGAATGGGCTTTGCAATTCCTTCAAACGATGTTGTCTCTATTATTAATCAATTAGAAGAAAATGGTG
AAGTTGTTAGACCCGCTCTTGGTATTTCAATGGCTAATCTTAGTGAAGCTTCAACAAGTGGAAGAGATACTTTAAAAATA
CCAAGTGATGTCACAAGCGGTATTGTTGTTCTTTCAACACAAAGTGGTATGCCAGCAGATGGGAAGCTGAAGAAATATGA
TGTCATTACAGAAATTGATGGGAAGAAGGTAGCGTCTATCAGCGATCTTCAAAGTATTCTTTACAAACACAAAAAGGGAG
ATAAAATTAAACTCACTTTCTATCGCGAAAAAGATAAACAAACAGTTGAGATCCAATTAACTAAAACAAGTCAAGATTTG
AATCATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(298-393)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

Peptidase family M50 (Peptidase_M50)

(227-398)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DRQ6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

100

100

1
  htrA Streptococcus gordonii str. Challis substr. CH1

56.14

99.254

0.557
  htrA Streptococcus mitis NCTC 12261

54.684

98.259

0.537
  htrA Streptococcus pneumoniae Rx1

54.315

98.01

0.532
  htrA Streptococcus pneumoniae D39

54.315

98.01

0.532
  htrA Streptococcus pneumoniae R6

54.315

98.01

0.532
  htrA Streptococcus pneumoniae TIGR4

54.315

98.01

0.532