Detailed information NTG0704441

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NKZ65_RS04495
• Genome accession: NZ_CP100332
• Coordinates: 880440..881111 (+)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis strain STC84
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 875440..886111

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NKZ65_RS04465 (NKZ65_04465)	pstC	875623..876540 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
NKZ65_RS04470 (NKZ65_04470)	pstA	876530..877417 (+)	888	WP_002937616.1	phosphate ABC transporter permease PstA	-
NKZ65_RS04475 (NKZ65_04475)	pstB	877442..878245 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
NKZ65_RS04480 (NKZ65_04480)	pstB	878257..879015 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
NKZ65_RS04485 (NKZ65_04485)	phoU	879044..879700 (+)	657	WP_012028219.1	phosphate signaling complex protein PhoU	-
NKZ65_RS11280	-	879866..880000 (+)	135	WP_255304292.1	hypothetical protein	-
NKZ65_RS04490 (NKZ65_04490)	-	880058..880246 (+)	189	WP_226313374.1	hypothetical protein	-
NKZ65_RS04495 (NKZ65_04495)	ciaR	880440..881111 (+)	672	WP_009909965.1	response regulator transcription factor	Regulator
NKZ65_RS04500 (NKZ65_04500)	ciaH	881104..882483 (+)	1380	WP_002935290.1	cell wall metabolism sensor histidine kinase WalK	Regulator
NKZ65_RS04505 (NKZ65_04505)	-	882807..884036 (+)	1230	WP_024417479.1	transglutaminase domain-containing protein	-
NKZ65_RS04510 (NKZ65_04510)	rpsT	884298..884546 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
NKZ65_RS04515 (NKZ65_04515)	coaA	884605..885525 (-)	921	WP_024381359.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=704441 NKZ65_RS04495 WP_009909965.1 880440..881111(+) (ciaR) [Streptococcus suis strain STC84]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=704441 NKZ65_RS04495 WP_009909965.1 880440..881111(+) (ciaR) [Streptococcus suis strain STC84]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGCCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363