Detailed information NTG0704386

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NKZ80_RS04485
• Genome accession: NZ_CP100330
• Coordinates: 878152..878823 (+)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis strain STC85
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 873152..883823

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NKZ80_RS04455 (NKZ80_04455)	pstC	873335..874252 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
NKZ80_RS04460 (NKZ80_04460)	pstA	874242..875129 (+)	888	WP_002937616.1	phosphate ABC transporter permease PstA	-
NKZ80_RS04465 (NKZ80_04465)	pstB	875154..875957 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
NKZ80_RS04470 (NKZ80_04470)	pstB	875969..876727 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
NKZ80_RS04475 (NKZ80_04475)	phoU	876756..877412 (+)	657	WP_012028219.1	phosphate signaling complex protein PhoU	-
NKZ80_RS11270	-	877578..877712 (+)	135	WP_255304292.1	hypothetical protein	-
NKZ80_RS04480 (NKZ80_04480)	-	877770..877958 (+)	189	WP_226313374.1	hypothetical protein	-
NKZ80_RS04485 (NKZ80_04485)	ciaR	878152..878823 (+)	672	WP_009909965.1	response regulator transcription factor	Regulator
NKZ80_RS04490 (NKZ80_04490)	ciaH	878816..880195 (+)	1380	WP_002935290.1	cell wall metabolism sensor histidine kinase WalK	Regulator
NKZ80_RS04495 (NKZ80_04495)	-	880519..881748 (+)	1230	WP_024417479.1	transglutaminase domain-containing protein	-
NKZ80_RS04500 (NKZ80_04500)	rpsT	882010..882258 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
NKZ80_RS04505 (NKZ80_04505)	coaA	882317..883237 (-)	921	WP_024381359.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=704386 NKZ80_RS04485 WP_009909965.1 878152..878823(+) (ciaR) [Streptococcus suis strain STC85]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=704386 NKZ80_RS04485 WP_009909965.1 878152..878823(+) (ciaR) [Streptococcus suis strain STC85]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGCCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTAATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363