Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   NEE09_RS08585 Genome accession   NZ_CP099641
Coordinates   1649056..1649793 (-) Length   245 a.a.
NCBI ID   WP_001219120.1    Uniprot ID   Q9S1I6
Organism   Streptococcus pneumoniae strain ATCC 700671     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1644056..1654793
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NEE09_RS08565 comA/nlmT 1644433..1646076 (+) 1644 WP_078133841.1 peptide cleavage/export ABC transporter Regulator
  NEE09_RS08570 - 1646087..1647448 (+) 1362 WP_001069091.1 bacteriocin secretion accessory protein -
  NEE09_RS08575 blpC 1647505..1647660 (+) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  NEE09_RS08580 - 1647702..1649042 (-) 1341 WP_001017638.1 sensor histidine kinase -
  NEE09_RS08585 comE/blpR 1649056..1649793 (-) 738 WP_001219120.1 LytTR family DNA-binding domain-containing protein Regulator
  NEE09_RS08590 - 1649798..1650136 (-) 339 WP_000682135.1 LytTR family DNA-binding domain-containing protein -
  NEE09_RS08595 - 1650413..1650742 (+) 330 WP_000132572.1 hypothetical protein -
  NEE09_RS08600 - 1650910..1651959 (-) 1050 WP_000653767.1 ABC transporter permease -
  NEE09_RS08605 pptA 1651956..1652687 (-) 732 WP_000889925.1 ABC transporter ATP-binding protein Regulator
  NEE09_RS08610 - 1652755..1653165 (+) 411 WP_001278299.1 HIT family protein -
  NEE09_RS08615 - 1653175..1653462 (+) 288 WP_000777760.1 hypothetical protein -
  NEE09_RS08620 - 1653624..1653863 (+) 240 WP_001810235.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28754.98 Da        Isoelectric Point: 6.5884

>NTDB_id=701222 NEE09_RS08585 WP_001219120.1 1649056..1649793(-) (comE/blpR) [Streptococcus pneumoniae strain ATCC 700671]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=701222 NEE09_RS08585 WP_001219120.1 1649056..1649793(-) (comE/blpR) [Streptococcus pneumoniae strain ATCC 700671]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1I6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.017

98.776

0.376
  comE Streptococcus infantis strain Atu-4

35.887

100

0.363