Detailed information NTG0069468

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SR187_RS09825
• Genome accession: NZ_AP018400
• Coordinates: 2088208..2089383 (+)
• Length: 391 a.a.
• NCBI ID: WP_120172442.1
• Uniprot ID: A0A2Z5TTG3
• Organism: Streptococcus ruminantium strain GUT-187
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2083208..2094383

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SR187_RS09795 (SR187_10110)	-	2083838..2086414 (+)	2577	WP_120172441.1	YfhO family protein	-
SR187_RS09815 (SR187_10130)	-	2086828..2087512 (-)	685	Protein_1875	YoaK family protein	-
SR187_RS09820 (SR187_10135)	rlmH	2087537..2088016 (-)	480	WP_024531474.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SR187_RS09825 (SR187_10140)	htrA	2088208..2089383 (+)	1176	WP_120172442.1	S1C family serine protease	Regulator
SR187_RS09830 (SR187_10145)	spo0J	2089444..2090241 (+)	798	WP_120172443.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 391 a.a.
• Molecular weight: 41593.05 Da
• Isoelectric Point: 8.9096

>NTDB_id=69468 SR187_RS09825 WP_120172442.1 2088208..2089383(+) (htrA) [Streptococcus ruminantium strain GUT-187]
MKKYLKFTILFAVGLLGGLVGSFMTASFFQPQAQQQANSTITNVSKVQYNNETSTTKAVEKVQNAVVSVINYQKSANNSL
RSIFGNIDTPDEPVVAGEGSGVIYKKDDKYAYVVTNTHVINNAEKIDILLTSGEKVRGELVGSDTYSDIAVIRIPADKVT
TVAEFANSNTIKVGEPAIAIGSPLGSVYANTVTQGIISSLSRTITSQSEDGQTISTNAIQTDAAINPGNSGGPLINIKGQ
VVGINSSKKSTSRSGVAIEGMGFAIPANDVVAIINQIEKNGKVIRPALGFQLVNLTDLSTGQLEKAGLSDTKLTSGVVVV
STQKGLPADGKLETFDVITEINGEAVQNKSDLQSILYKHKIGDTIKVTYYRNNKKQTVDIKLTHSTEQLSQ

Nucleotide

• Length: 1176 bp

>NTDB_id=69468 SR187_RS09825 WP_120172442.1 2088208..2089383(+) (htrA) [Streptococcus ruminantium strain GUT-187]
ATGAAAAAATATTTGAAATTTACTATTCTGTTTGCTGTTGGTCTTTTGGGTGGTTTAGTTGGTTCTTTCATGACTGCCTC
TTTCTTTCAACCACAAGCACAACAACAGGCAAATTCTACTATTACAAATGTCAGCAAGGTGCAATACAATAATGAGACCT
CTACTACAAAAGCAGTAGAAAAGGTGCAAAATGCTGTTGTTTCAGTAATTAACTATCAAAAATCAGCAAACAATAGCCTA
CGCTCCATCTTCGGAAATATTGATACACCGGATGAACCTGTAGTAGCTGGAGAAGGTTCGGGTGTTATCTATAAAAAAGA
CGATAAATATGCCTACGTTGTTACCAATACGCATGTTATCAATAACGCAGAAAAAATAGATATTCTTCTAACTTCAGGAG
AAAAGGTCAGAGGAGAACTTGTTGGTTCTGACACTTATTCTGACATAGCTGTAATAAGGATTCCTGCTGATAAGGTCACT
ACTGTTGCCGAATTTGCTAACTCCAATACTATCAAGGTCGGTGAACCTGCTATCGCTATCGGTAGCCCACTTGGTAGTGT
CTATGCTAATACTGTTACACAAGGTATTATTTCTAGTTTGAGTAGAACTATCACCTCACAATCAGAAGATGGACAAACTA
TCTCTACCAACGCTATCCAAACAGATGCAGCCATTAACCCAGGTAATTCAGGTGGTCCACTGATAAATATTAAAGGACAA
GTTGTGGGGATCAATTCAAGTAAAAAGAGTACATCGAGATCCGGTGTTGCTATAGAAGGGATGGGCTTTGCTATTCCTGC
TAATGATGTAGTAGCTATTATCAATCAAATTGAGAAAAATGGTAAAGTTATCCGACCTGCTCTCGGTTTCCAACTAGTCA
ATTTGACAGATTTGTCAACTGGACAATTAGAAAAAGCTGGATTATCAGATACCAAATTAACATCTGGTGTTGTAGTTGTT
TCAACGCAGAAGGGGTTACCTGCTGATGGAAAACTTGAAACCTTTGATGTTATCACTGAGATTAACGGTGAAGCTGTTCA
AAATAAGAGCGATCTTCAAAGTATCCTCTACAAGCATAAAATTGGTGATACGATTAAGGTTACCTACTATCGTAACAATA
AAAAGCAAACAGTTGACATCAAGTTGACACATTCTACGGAGCAACTCAGTCAATAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (99-244)

• PDZ domain (PDZ_2) (286-382)

3D structure

• AlphaFold DB: A0A2Z5TTG3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	59.494	100	0.601
htrA	Streptococcus gordonii str. Challis substr. CH1	59.184	100	0.593
htrA	Streptococcus pneumoniae Rx1	55.784	99.488	0.555
htrA	Streptococcus pneumoniae D39	55.784	99.488	0.555
htrA	Streptococcus pneumoniae R6	55.784	99.488	0.555
htrA	Streptococcus pneumoniae TIGR4	55.784	99.488	0.555
htrA	Streptococcus mitis NCTC 12261	55.784	99.488	0.555