Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   STO1_RS09450 Genome accession   NZ_AP018338
Coordinates   1843151..1845304 (-) Length   717 a.a.
NCBI ID   WP_096422947.1    Uniprot ID   A0A224A9A4
Organism   Streptococcus oralis subsp. tigurinus strain osk_001     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1838151..1850304
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STO1_RS09440 (STO1_017880) purC 1840915..1841622 (-) 708 WP_033583550.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  STO1_RS09445 (STO1_017890) comB 1841789..1843138 (-) 1350 WP_096422945.1 competence pheromone export protein ComB Regulator
  STO1_RS09450 (STO1_017900) comA 1843151..1845304 (-) 2154 WP_096422947.1 peptide cleavage/export ABC transporter ComA Regulator
  STO1_RS09460 (STO1_017920) - 1845740..1845928 (-) 189 WP_061588472.1 hypothetical protein -
  STO1_RS09465 (STO1_017930) - 1845967..1846137 (-) 171 WP_007522555.1 H354_08695 family bacteriocin-like peptide -
  STO1_RS09475 (STO1_017950) - 1846369..1846545 (-) 177 WP_007522553.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  STO1_RS09775 (STO1_017960) - 1846828..1847004 (-) 177 WP_021164730.1 hypothetical protein -
  STO1_RS09480 (STO1_017970) - 1846985..1847221 (-) 237 WP_007522551.1 acyl carrier protein -
  STO1_RS09485 (STO1_017980) plsX 1847227..1848219 (-) 993 WP_096422949.1 phosphate acyltransferase PlsX -
  STO1_RS09490 (STO1_017990) recO 1848216..1848986 (-) 771 WP_096422951.1 DNA repair protein RecO -
  STO1_RS09495 (STO1_018000) - 1848983..1850152 (-) 1170 WP_096422953.1 pyridoxal phosphate-dependent aminotransferase -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80542.70 Da        Isoelectric Point: 6.8359

>NTDB_id=69095 STO1_RS09450 WP_096422947.1 1843151..1845304(-) (comA) [Streptococcus oralis subsp. tigurinus strain osk_001]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLSDL
TFPFVAHVLKEGKLLHYYVVIGQDKKHIHIADPDPSVKLTKISRERFEQEWTGVSIFMAPSPDYKPHKEKKQGLLSFLPI
LLKQRGLITNIVLATLLVTLINIVGSYYLQSIIDSYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTILIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESSRYQKIDKEFVAYLKKSFTYSRAESQQKALKKVAQL
LLNVAVLWLGAILVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSMM
KGEMTFKQVHYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKSLRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTERVVVLDQGKIVEEGNHADLLARGEFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=69095 STO1_RS09450 WP_096422947.1 1843151..1845304(-) (comA) [Streptococcus oralis subsp. tigurinus strain osk_001]
ATGAAATTTGGGAAAAGGCACTATCGTCCCCAGGTGGATCAGATGGATTGTGGCGTGGCTTCCTTGGCCATGGTATTTGG
CTACTATGGTAGTTATTACTCCTTAGCTCACTTGCGAGAGTTAGCCAAGACGACCATGGATGGGACAACTGCATTGGGTC
TTGTAAAGGTAGCAGAGGAGATTGGTTTTGAAACACGGGCTATCAAGGCGGATATGACACTCTTTGATTTGTCCGATTTG
ACCTTTCCTTTTGTGGCCCATGTGCTCAAGGAAGGGAAGTTGCTCCACTACTATGTGGTGATAGGTCAGGATAAAAAGCA
CATTCATATCGCTGATCCAGATCCTAGTGTTAAGCTGACCAAGATTTCCCGTGAGCGATTTGAGCAAGAATGGACAGGGG
TTAGTATTTTTATGGCACCATCACCGGACTATAAACCTCATAAGGAGAAAAAACAGGGACTCCTATCCTTCTTGCCGATC
TTACTCAAACAGCGTGGCTTGATTACCAATATCGTCCTAGCGACACTCTTGGTAACCTTGATCAATATTGTGGGTTCCTA
CTACCTTCAGTCCATCATTGATAGTTACGTGCCAGACCAGATGCGCTCGACCTTGGGCATTATCTCAATAGGACTAGTCA
TCGTCTATATCCTCCAGCAGATTTTGTCTTATGCGCAAGAATACCTCTTACTTGTTCTGGGGCAACGGTTGTCCATCGAT
GTGATTTTGTCCTATATCAAGCATGTTTTTCATCTGCCGATGTCCTTTTTCGCGACACGCAGGACAGGAGAGATCGTATC
TCGCTTTACGGACGCCAATAGCATCATCGATGCGCTAGCGTCGACCATTCTGTCTATCTTTTTGGATGTGTCGACGATTT
TGATTATCTCACTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCACTTCCCATCTATACCGTG
ATCATCTTTGCCTTTATGAAGCCTTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCCTCTAT
CATTGAGGACATCAATGGTATTGAGACGATTAAGTCCTTGACCAGTGAAAGCTCACGCTATCAAAAGATTGATAAGGAAT
TTGTAGCTTATCTGAAAAAATCCTTTACCTATAGTCGGGCAGAAAGTCAGCAAAAGGCTCTGAAAAAAGTTGCTCAGCTC
CTGCTCAATGTTGCCGTTCTCTGGCTGGGAGCTATTCTGGTCATGGATGGGAAAATGAGTTTGGGCCAGCTGATTACCTA
TAACACCCTGCTTGTTTACTTTACCAATCCTTTGGAAAATATCATTAACCTACAAACCAAACTTCAGACAGCGCAGGTTG
CCAATAATCGCTTAAATGAGGTTTATCTAGTAGCTTCGGAGTTTGAGGAGAAGAAAACGGTAGAAGATTTGAGCATGATG
AAGGGAGAGATGACCTTCAAGCAGGTTCACTATAAGTATGGCTATGGTCGTGATGTCTTGTCGGATATCAATTTGACCAT
TCCGCAAGGGTCTAAGGTAGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACCTTAGCCAAGATGATGGTTAATTTCT
ATGACCCTAGTCAGGGAGAGATTAGCCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAATCCTTGCGTCAGTATATC
AACTACCTACCTCAACAGCCCTATGTCTTTAATGGGACGATTTTGGAGAATCTGCTCCTTGGAGCCAAGGAAGGGACGAC
TCAGGAAGATATCTTACGAGCGGTTGAATTGGCTGAGATTCGAGAAGATATCGAGCGGATGCCGCTGAATTATCAGACAG
AATTGACTTCGGATGGGGCAGGTATTTCTGGGGGGCAACGGCAGAGAATTGCTTTGGCGCGTGCTCTTTTAACGGATGCG
CCTGTTCTGATATTGGACGAGGCGACCAGCAGTCTGGATATCTTGACAGAGAAGCGGATCGTGGATAATCTCATGGCTTT
AGACAAGACCTTGATTTTCATTGCTCACCGCTTGACCATTGCTGAGCGGACAGAGAGGGTTGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGCAACCATGCAGACTTGCTTGCCCGAGGTGAATTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-650)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A224A9A4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

94.979

100

0.95
  comA Streptococcus pneumoniae D39

94.979

100

0.95
  comA Streptococcus pneumoniae R6

94.979

100

0.95
  comA Streptococcus mitis NCTC 12261

94.84

100

0.948
  comA Streptococcus mitis SK321

94.7

100

0.947
  comA Streptococcus pneumoniae TIGR4

94.561

100

0.946
  comA Streptococcus gordonii str. Challis substr. CH1

80.753

100

0.808
  comA/nlmT Streptococcus mutans UA159

64.854

100

0.649

Multiple sequence alignment