Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   STO1_RS09445 Genome accession   NZ_AP018338
Coordinates   1841789..1843138 (-) Length   449 a.a.
NCBI ID   WP_096422945.1    Uniprot ID   A0A224A7Y0
Organism   Streptococcus oralis subsp. tigurinus strain osk_001     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1836789..1848138
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STO1_RS09435 (STO1_017870) - 1837175..1840900 (-) 3726 WP_096422943.1 phosphoribosylformylglycinamidine synthase -
  STO1_RS09440 (STO1_017880) purC 1840915..1841622 (-) 708 WP_033583550.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  STO1_RS09445 (STO1_017890) comB 1841789..1843138 (-) 1350 WP_096422945.1 competence pheromone export protein ComB Regulator
  STO1_RS09450 (STO1_017900) comA 1843151..1845304 (-) 2154 WP_096422947.1 peptide cleavage/export ABC transporter ComA Regulator
  STO1_RS09460 (STO1_017920) - 1845740..1845928 (-) 189 WP_061588472.1 hypothetical protein -
  STO1_RS09465 (STO1_017930) - 1845967..1846137 (-) 171 WP_007522555.1 H354_08695 family bacteriocin-like peptide -
  STO1_RS09475 (STO1_017950) - 1846369..1846545 (-) 177 WP_007522553.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  STO1_RS09775 (STO1_017960) - 1846828..1847004 (-) 177 WP_021164730.1 hypothetical protein -
  STO1_RS09480 (STO1_017970) - 1846985..1847221 (-) 237 WP_007522551.1 acyl carrier protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 50040.07 Da        Isoelectric Point: 5.1394

>NTDB_id=69094 STO1_RS09445 WP_096422945.1 1841789..1843138(-) (comB) [Streptococcus oralis subsp. tigurinus strain osk_001]
MKPEFLESAEFYHRRYHNFSSRVIVPMSLLLVFLFGFAVFAEKEISLSTRATIEPSRIISNIQSTSNQRIVANYLEENKL
VKQGDLLVQYQQGAEAVQAEAYASQLDMLKDQKKQLEYLQKSLQEGGNHFPEEDKFGYQEMFRDYLSQASSLRSNVSQQN
ANISSQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGDQLDSQNVAYSFYQTYKNQGAEDPRAKSQVIAQVDVQIA
QLESGLATYRVQYAGSGAQQAYASGLDSQLESLKSQHLVKVGQELTLLDQKILEAESGKKVQGGLLDKGKIIASEDGVLH
LNPETSDSTMVAEGTLLAQLYPALEREGKTKLTAYLSSKDVARLKVGDSVRFTTSKDANKELVLVSAITNIDATATKTEK
GNFFKIEAETSLTPEQAEQLRYGVEGRLQMITGRKSYLRYYLDQFLNQE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=69094 STO1_RS09445 WP_096422945.1 1841789..1843138(-) (comB) [Streptococcus oralis subsp. tigurinus strain osk_001]
ATGAAACCAGAATTTTTAGAAAGCGCAGAGTTTTACCATCGTCGTTACCATAATTTTTCCAGTCGCGTGATTGTACCCAT
GTCGCTTTTGCTCGTGTTTCTGTTTGGATTTGCAGTCTTTGCAGAGAAGGAGATCAGTTTGTCTACTAGAGCTACTATCG
AACCTAGTCGAATCATTTCCAACATCCAGTCGACTAGCAATCAACGTATTGTGGCCAATTATCTAGAAGAGAACAAACTT
GTCAAGCAGGGTGATCTACTCGTTCAGTACCAGCAAGGGGCGGAAGCTGTCCAAGCGGAGGCCTATGCTAGTCAGTTGGA
CATGCTCAAGGATCAAAAAAAGCAGTTGGAGTATTTGCAGAAGAGCCTGCAAGAAGGGGGGAACCACTTTCCAGAGGAGG
ATAAGTTTGGATATCAGGAGATGTTTCGAGACTATCTCAGCCAAGCTAGTAGTCTTAGGAGCAATGTTTCGCAGCAAAAT
GCCAACATCTCCTCGCAGAATGCGGCAGCTAGTCAAACCCAAGCCGAAATCGGCAACCTCATTAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCGGCGATTGAAACAGGAGATCAACTGGATAGTCAAAATGTAGCCTACTCATTTT
ATCAGACCTATAAAAATCAAGGTGCAGAAGATCCACGAGCTAAATCGCAAGTTATTGCTCAGGTGGATGTACAAATCGCC
CAGCTAGAGTCTGGTTTAGCTACTTATCGTGTGCAGTATGCGGGTTCTGGAGCTCAACAAGCCTACGCAAGTGGACTGGA
TAGTCAGCTTGAATCCCTCAAGTCTCAGCACCTAGTCAAAGTCGGTCAAGAATTAACCCTTTTGGATCAGAAAATTTTGG
AGGCAGAGTCGGGTAAGAAAGTCCAAGGAGGTCTGCTGGACAAGGGGAAAATTATAGCAAGCGAGGACGGTGTGCTTCAC
CTTAATCCTGAAACCAGTGATTCTACCATGGTTGCAGAAGGCACCTTGCTCGCTCAACTCTACCCAGCCTTGGAACGAGA
AGGTAAAACTAAACTCACAGCTTATCTCAGTTCAAAAGATGTTGCAAGGCTCAAGGTCGGTGATTCTGTTCGTTTCACTA
CAAGCAAAGATGCCAACAAAGAGCTCGTTCTTGTTTCTGCCATTACGAATATTGATGCGACAGCTACCAAGACTGAAAAG
GGAAATTTCTTTAAAATAGAGGCGGAGACCAGTCTGACTCCTGAGCAGGCAGAACAACTTCGCTATGGGGTGGAAGGTCG
CCTGCAGATGATTACAGGCAGGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACCAAGAGTAA

Domains

Predicted by InterproScan.

HlyD family secretion protein (HlyD_3)

(311-423)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A224A7Y0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus mitis SK321

83.742

100

0.837
  comB Streptococcus pneumoniae Rx1

83.519

100

0.835
  comB Streptococcus pneumoniae D39

83.519

100

0.835
  comB Streptococcus pneumoniae R6

83.519

100

0.835
  comB Streptococcus pneumoniae TIGR4

83.073

100

0.831
  comB Streptococcus mitis NCTC 12261

82.183

100

0.822
  comB Streptococcus gordonii str. Challis substr. CH1

55.778

100

0.559

Multiple sequence alignment