Detailed information NTG0069065

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: STO1_RS05845
• Genome accession: NZ_AP018338
• Coordinates: 1157596..1158270 (-)
• Length: 224 a.a.
• NCBI ID: WP_000590630.1
• Uniprot ID: A0A4V0BT06
• Organism: Streptococcus oralis subsp. tigurinus strain osk_001
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1152596..1163270

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
STO1_RS05820 (STO1_011320)	-	1152738..1153667 (-)	930	WP_096422392.1	peptidase U32 family protein	-
STO1_RS05825 (STO1_011330)	-	1153794..1154474 (-)	681	WP_096422394.1	ABC transporter ATP-binding protein	-
STO1_RS05830 (STO1_011340)	-	1154488..1155543 (-)	1056	WP_096422396.1	ABC transporter permease	-
STO1_RS05835 (STO1_011350)	-	1155921..1156205 (+)	285	WP_007521610.1	DUF3270 domain-containing protein	-
STO1_RS05840 (STO1_011360)	ciaH	1156269..1157606 (-)	1338	WP_007521609.1	sensor histidine kinase	Regulator
STO1_RS05845 (STO1_011370)	ciaR	1157596..1158270 (-)	675	WP_000590630.1	two-component system response regulator CiaR	Regulator
STO1_RS05850 (STO1_011380)	-	1158380..1160926 (-)	2547	WP_096422398.1	M1 family metallopeptidase	-
STO1_RS05855 (STO1_011390)	-	1161048..1161488 (-)	441	WP_061588106.1	ASCH domain-containing protein	-
STO1_RS05860 (STO1_011400)	-	1161485..1161982 (-)	498	WP_007521606.1	NUDIX hydrolase	-
STO1_RS05865 (STO1_011410)	-	1162022..1162627 (-)	606	WP_096422400.1	DUF6707 family protein	-
STO1_RS05870 (STO1_011420)	-	1162679..1163050 (-)	372	WP_007521602.1	Imm51 family immunity protein	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25479.29 Da
• Isoelectric Point: 4.2660

>NTDB_id=69065 STO1_RS05845 WP_000590630.1 1157596..1158270(-) (ciaR) [Streptococcus oralis subsp. tigurinus strain osk_001]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide

• Length: 675 bp

>NTDB_id=69065 STO1_RS05845 WP_000590630.1 1157596..1158270(-) (ciaR) [Streptococcus oralis subsp. tigurinus strain osk_001]
ATGATAAAAATCTTATTAGTAGAAGATGACCTAGGTCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT
CATGCAGGTCTTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGACTTGATTCTGCTTGACCTCATGT
TACCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTACGTGAAAAAGGAATTACAACCCCTGTCCTTATCATGACCGCT
AAGGAAAGTTTGGATGACAAGGGTCATGGATTTGAATTGGGTGCGGATGACTACCTCACCAAACCTTTCTATCTAGAAGA
ACTCAAAATGCGGATCCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAACGAAAACACCTTGACCTATGGGGATATTGTCG
TCAACCTTTCAACGAATGAGGTTAAGGTGGAAGACACGCCTGTGGAACTACTCGGAAAAGAGTTTGAGTTATTGGTTTAT
TTCCTTCAAAATCAAAATGTTATTCTTCCTAAGACGCAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACGAT
TTCCGTTGTAGAAGTCTATGTTTCAAAAGTTCGTAAGAAATTGAAGGGGACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATATTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A4V0BT06

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae TIGR4	97.768	100	0.978
ciaR	Streptococcus pneumoniae D39	97.768	100	0.978
ciaR	Streptococcus pneumoniae R6	97.768	100	0.978
ciaR	Streptococcus pneumoniae Rx1	97.768	100	0.978
ciaR	Streptococcus mutans UA159	87.5	100	0.875
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366