Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   STO1_RS05840 Genome accession   NZ_AP018338
Coordinates   1156269..1157606 (-) Length   445 a.a.
NCBI ID   WP_007521609.1    Uniprot ID   A0A0F2E354
Organism   Streptococcus oralis subsp. tigurinus strain osk_001     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1151269..1162606
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STO1_RS05815 (STO1_011310) rpiA 1151949..1152632 (-) 684 WP_096422390.1 ribose-5-phosphate isomerase RpiA -
  STO1_RS05820 (STO1_011320) - 1152738..1153667 (-) 930 WP_096422392.1 peptidase U32 family protein -
  STO1_RS05825 (STO1_011330) - 1153794..1154474 (-) 681 WP_096422394.1 ABC transporter ATP-binding protein -
  STO1_RS05830 (STO1_011340) - 1154488..1155543 (-) 1056 WP_096422396.1 ABC transporter permease -
  STO1_RS05835 (STO1_011350) - 1155921..1156205 (+) 285 WP_007521610.1 DUF3270 domain-containing protein -
  STO1_RS05840 (STO1_011360) ciaH 1156269..1157606 (-) 1338 WP_007521609.1 sensor histidine kinase Regulator
  STO1_RS05845 (STO1_011370) ciaR 1157596..1158270 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  STO1_RS05850 (STO1_011380) - 1158380..1160926 (-) 2547 WP_096422398.1 M1 family metallopeptidase -
  STO1_RS05855 (STO1_011390) - 1161048..1161488 (-) 441 WP_061588106.1 ASCH domain-containing protein -
  STO1_RS05860 (STO1_011400) - 1161485..1161982 (-) 498 WP_007521606.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50762.47 Da        Isoelectric Point: 9.6796

>NTDB_id=69064 STO1_RS05840 WP_007521609.1 1156269..1157606(-) (ciaH) [Streptococcus oralis subsp. tigurinus strain osk_001]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKTNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMVLMETNSSTVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANYELIASENDRVFNYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLSVTDNGIGISAADKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTITVKDNKPRGTIFEVKIAIQSPPKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=69064 STO1_RS05840 WP_007521609.1 1156269..1157606(-) (ciaH) [Streptococcus oralis subsp. tigurinus strain osk_001]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGCTATTTCATTCGAAACTTCGGAGTGTTCACCCTGAT
TTTCTCTGCTATGACCTTGATTATCCTTCAGGTCATGCACTCGAGTCTCTACACCTCTGTAGATGAAAAACTACAAGCCC
TTAGTAGTAGTCCTCAAGCGGTTATCCAGTTAGCCCTGAATCGGGCCACCGAAGAGGTCAAGGATATTCAACCCGCAACA
GCGGATGCCAGCAAGGCTGAAATCAAGACCAATGTTAGCTCTAATACAGAAGTTTTGCTTTTTGATAAGGATTTTAACCA
ACTCTTACTGGGCAATCGCTTTTTAGGCTTGGACAAGATCAAGCTGGACAAGAAAGAGTTGAATCACATTCGCCAAATCC
AAGTTGTCAATAGCTATGGTCAGGAAGAAACCTACCGAATGGTCTTGATGGAAACCAATTCATCCACTGTTTCAAGTAAT
GTCAAATATGCGGCGGTTTTAATCAATACCAGCCAGCTTGAGCAAATCAGCCAAAACCACGAGCATTTAATTGTTGTAGT
TATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTACCTGGCACGTGTCAGTGTCAAACCTCTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCGAGTCACGAACTGAGAACGCCTTTGGCCGTTTTACAAAATCGTTTAGAG
ACTCTCTTTCGAAAACCAGAGGCAACGATTATGGAATCCAGCGAAAGCATTGCTTCTAGTCTTGAAGAAGTTCGCAATAT
GCGCTTCCTCACGACCAATCTTCTCAACCTTGCACGTCGAGATGATGGAATCAAACCAGAAATAGCAGAAGTTTCTCCAC
AATTCTTTAAAACAACCTTTGCCAACTATGAGTTGATTGCTTCTGAAAATGATCGTGTTTTCAACTATGAAAATCGAATT
TATCGTCCATTCATGACCGATCAGTTGCTCCTAAAACAGCTCATGACCATCTTGTTTGATAATGCCATCAAGTATACCGA
AGAAGATGGAAAGATTGAGTTTGTGGTCCATGCTACGGATCGCCACCTCTATCTATCCGTAACGGATAATGGAATTGGGA
TCTCAGCTGCCGATAAGAAGAAAATCTTTGACCGTTTTTACCGTGTAGACAAGGCGAGAACCCGTCAGAAAGGTGGGTTT
GGTCTGGGACTATCTTTGGCCAAGCAGATCGTAGATGCCTTACGAGGAACGATTACCGTTAAAGATAACAAGCCTAGAGG
AACAATTTTTGAAGTTAAGATTGCTATTCAATCTCCTCCCAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F2E354

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae D39

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae R6

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae TIGR4

83.973

99.551

0.836
  ciaH Streptococcus mutans UA159

55.479

98.427

0.546

Multiple sequence alignment