Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SNAG_RS06110 Genome accession   NZ_AP017652
Coordinates   1177529..1178203 (-) Length   224 a.a.
NCBI ID   WP_061453486.1    Uniprot ID   A0A139PRA9
Organism   Streptococcus sp. NPS 308     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1172529..1183203
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SNAG_RS06085 (SNAG_1191) - 1172662..1173591 (-) 930 WP_096407542.1 peptidase U32 family protein -
  SNAG_RS06090 (SNAG_1192) - 1173718..1174398 (-) 681 WP_096407544.1 ABC transporter ATP-binding protein -
  SNAG_RS06095 (SNAG_1193) - 1174412..1175467 (-) 1056 WP_096407546.1 ABC transporter permease -
  SNAG_RS06100 (SNAG_1194) - 1175853..1176137 (+) 285 WP_096407548.1 DUF3270 domain-containing protein -
  SNAG_RS06105 (SNAG_1195) ciaH 1176202..1177539 (-) 1338 WP_096407550.1 HAMP domain-containing sensor histidine kinase Regulator
  SNAG_RS06110 (SNAG_1196) ciaR 1177529..1178203 (-) 675 WP_061453486.1 two-component system response regulator CiaR Regulator
  SNAG_RS06115 (SNAG_1197) - 1178314..1180860 (-) 2547 WP_096407552.1 M1 family metallopeptidase -
  SNAG_RS06120 (SNAG_1198) - 1180982..1181422 (-) 441 WP_096408864.1 ASCH domain-containing protein -
  SNAG_RS06125 - 1181478..1181738 (-) 261 WP_231906657.1 hypothetical protein -
  SNAG_RS06130 (SNAG_1199) - 1181857..1182411 (-) 555 WP_096407556.1 DUF4304 domain-containing protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25479.29 Da        Isoelectric Point: 4.2660

>NTDB_id=68354 SNAG_RS06110 WP_061453486.1 1177529..1178203(-) (ciaR) [Streptococcus sp. NPS 308]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDVIVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=68354 SNAG_RS06110 WP_061453486.1 1177529..1178203(-) (ciaR) [Streptococcus sp. NPS 308]
ATGATAAAAATCTTATTAGTAGAAGATGACCTAGGTCTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT
CATGCAGGTCTTTGATGGAGAAGAAGGTCTCTACGAAGCAGAAAGTGGCGTCTATGACTTGATTTTGCTTGACCTGATGT
TGCCGGAAAAAAATGGTTTCCAAGTCTTGAAAGAGTTGCGAGAAAAAGGAATCACGACACCAGTCCTTATCATGACCGCC
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTATCTCACCAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAAGCCCTTCTCAAGCGTTCAGGTAAGTTTAATGAAAACACCTTGACCTATGGGGATGTTATCG
TCAATCTTTCAACGAATGAAGTAAAAGTGGAAGATACTCCTGTGGAACTGCTCGGAAAAGAGTTTGAGTTATTGGTTTAC
TTCCTTCAAAATCAAAATGTCATTCTTCCCAAGACACAGATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACGAT
TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCATTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A139PRA9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

96.875

100

0.969
  ciaR Streptococcus pneumoniae D39

96.875

100

0.969
  ciaR Streptococcus pneumoniae R6

96.875

100

0.969
  ciaR Streptococcus pneumoniae Rx1

96.875

100

0.969
  ciaR Streptococcus mutans UA159

87.5

100

0.875
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

35.841

100

0.362

Multiple sequence alignment