Detailed information    

experimental Experimentally validated

Overview

Name   ccnC   Type   Regulator
Locus tag   - Genome accession   NC_003098
Coordinates   23967..24066 (+) Length   33.3333333333333 a.a.
NCBI ID   - Uniprot ID   -
Organism   Streptococcus pneumoniae R6     
Function   repress competence development   
Competence regulation

Function

Competence in S. pneumoniae is additively controlled by the csRNAs via post-transcriptional regulation of comC


Genomic Context

Location: 18967..29066
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPR_RS00100 - 20225..21071 (+) 847 Protein_14 IS630 family transposase -
  SPR_RS00105 - 21106..21902 (-) 797 Protein_15 transposase -
  SPR_RS00110 (spr0020) comW 22168..22404 (+) 237 WP_000939545.1 sigma(X)-activator ComW Regulator
  SPR_RS00115 (spr0021) - 22635..23921 (+) 1287 WP_000205044.1 adenylosuccinate synthase -
  - ccnC 23967..24066 (+) 100 - - Regulator
  SPR_RS00120 (spr0022) tadA 24122..24589 (+) 468 WP_000291874.1 tRNA adenosine(34) deaminase TadA -
  SPR_RS00130 (spr0023) - 24776..25219 (+) 444 WP_000701992.1 dUTP diphosphatase -
  SPR_RS00135 (spr0024) - 25221..25736 (+) 516 WP_000691236.1 histidine phosphatase family protein -
  SPR_RS00140 (spr0025) radA 25750..27111 (+) 1362 WP_074017595.1 DNA repair protein RadA Machinery gene
  SPR_RS00145 (spr0026) - 27184..27681 (+) 498 WP_025170955.1 beta-class carbonic anhydrase -
  SPR_RS00150 (spr0027) - 27706..28489 (+) 784 Protein_23 PrsW family glutamic-type intramembrane protease -

Regulatory network

Positive effect      
Negative effect
Regulator Target Regulation
  ccnC comC/comC1 negative effect
  comC/comC1 comD/comD1 positive effect
  comD/comD1 comE positive effect
  comE comB positive effect
  comB comC/comC1 positive effect
  comE comD/comD1 positive effect
  comA comC/comC1 positive effect
  comE comA positive effect
  ccnD comC/comC1 negative effect
  ccnE comC/comC1 negative effect
  comE comC/comC1 positive effect
  comE comW positive effect
  comE comX/comX1 positive effect
  comE comX/comX2 positive effect
  comE comM positive effect
  comE comE positive effect
  stkP comE positive effect
  htrA comC/comC1 negative effect
  htrA comEA/celA/cilE negative effect
  htrA comEC/celB negative effect
  ciaH htrA positive effect
  ciaR htrA positive effect
  ciaR comC/comC1 negative effect
  ccnA comC/comC1 negative effect
  ciaH comC/comC1 negative effect
  ccnB comC/comC1 negative effect
  comW comX/comX1 positive effect
  comW comX/comX2 positive effect
  clpP comW negative effect
  mecA comW negative effect
  clpC comW negative effect
  comX/comX1 late competence genes positive effect
  clpE comX/comX1 negative effect
  clpP comX/comX1 negative effect
  comX/comX2 late competence genes positive effect
  clpE comX/comX2 negative effect
  clpP comX/comX2 negative effect
  comM cbpD negative effect
  comX/comX2 late competence genes positive effect
  comX/comX1 late competence genes positive effect
  cbpD lytC positive effect
  cbpD lytA positive effect

Sequence

Nucleotide


Download         Length: 100 bp        

>NTDB_id=677 23967..24066(+) (ccnC) [Streptococcus pneumoniae R6]
GGTTACAAGAAGACCTCCTAACTTGTTGTAACAAATATCCTAAACTTTTCTTTTTCATAATAATCTCCCTATAGAGTCAC
CGCATTCGGTGGCTTTTTTT

References

[1] Anke Laux et al. (2015) Control of competence by related non-coding csRNAs in Streptococcus pneumoniae R6. Frontiers in Genetics 6:246. [PMID: 26257773]
[2] Anke Schnorpfeil et al. (2013) Target evaluation of the non-coding csRNAs reveals a link of the two-component regulatory system CiaRH to competence control in Streptococcus pneumoniae R6. Molecular Microbiology 89(2):334-49. [PMID: 23710838]
[3] Alexander Halfmann et al. (2007) Identification of the genes directly controlled by the response regulator CiaR in Streptococcus pneumoniae: five out of 15 promoters drive expression of small non-coding RNAs. Molecular Microbiology 66(1):110-26. [PMID: 17725562]